A new stilbene (1) was isolated from the root of Cassia sieberiana D. C. together with thirteen known compounds, one stilbene (2), three flavonoids (3–5), six anthraquinones (6–11), two triterpenes (12–13), and phytosterol (14). Their structures were identified using spectroscopic techniques and by comparison of the spectral data with those previously reported in the literature. Compounds 10 – 13 were isolated from C. sieberiana for the first time. Compounds 1, 2 and 3 exhibited significant inhibitory activity on 15-lipoxygenase with IC50 values of 2.62, 1.27 and 0.98 μM, respectively. Compounds 2 and 3 showed acetylcholinesterase inhibitory activity with IC50 values of 10.57 and 2.89 μM, respectively.
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