Two new withanolides, daturafoliside V (1) and daturafoliside W (2) with three known ones, daturametelin J (3), daturataturin A (4) and daturataturin B (5) were isolated from the pericarp of Datura metel L.. The structures of these compounds were identified by the analyses of spectroscopic data. And their inhibitory activities were evaluated by acting on RAW264.7 cells. Moreover, their molecular mechanisms are discussed based on the p-ERK, p-JNK, p-p38 and NF-κBp65 expression levels. As a result, the new one, compound 2 (IC50 38.3 μM) exhibited the potential immunosuppressive activity. Our datas indicate that studies on the pericarps of D. metel have great potential to discover new compounds and provide new resource for pharmacology research.
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