Three Tetracyclic Triterpenoic Acids from Dysoxylum densiflorum and Their Antibacterial Activities

Abstract

This paper reports the chemical isolation and antibacterial properties of terpenoid components of Dysoxylum densiflorum. Three new tetracyclic triterpenoic acids, densiflorinic acids A-C (1-3), were isolated from the acetone extract of the plant's leaves. The structures of the three compounds were determined mainly by extensive analysis of 1-D and 2-D NMR spectroscopic data. On antibacterial evaluation, the highest activity was shown by compound 1 against Bacillus subtilis with an IC₅₀ of 26.5 μM.

Keywords

Dysoxylum densiflorum Densiflorinic acids A-C Apotirucallane Tirucallane Antibacterial

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