The present study was aimed at evaluating the antibacterial activity of mulinane and azorellane diterpenes isolated from the Andean plants Azorella compacta and A. trifoliolata and semisynthetic derivatives against reference and multidrug-resistant strains. The results revealed that the semisynthetic compound 7-acetoxy-mulin-9,12-diene (5) exhibited antibacterial activity against reference and multidrug-resistant strains of Staphylococcus aureus and moderate antimycobacterial activity against Mycobacterium smegmatis ATCC 14468.
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2.
Molina-SalinasG., BorquezJ., ArdilesA., Said-FernandezS., LoyolaL., Yam-PucA., Becerril-MontesP., Escalante-ErosaF., San-MartínA., Gonzalez-ColladoI., Pena-RodriguezL. (2010) Bioactive metabolites from the Andean flora. Antituberculosis activity of natural and semisynthetic azorellane and mulinane diterpenoids. Phytochemistry Reviews, 9, 271–278.
3.
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9.
SatorresS., ChiaramelloA., MattanaC., AlcarazL., RossomandoP., TonnC., LaciarA. (2013) Azorella trifurcata and Mulinum echegarayii obtained from central region of Argentina: Antibacterial activity of their organic extracts. Emirates Journal of Food and Agriculture, 25, 457–462.
10.
LópezS., LimaB., AragónL., EspinarL.A., TapiaA., ZacchinoS., ZygadloJ., FeresinG.E., LópezM.L. (2012) Essential oil of Azorella cryptantha collected in two different locations from San Juan Province, Argentina: chemical variability and anti-insect and antimicrobial activities. Chemistry & Biodiversity, 9, 1452–1464.
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12.
BórquezJ., ArdilesA., LoyolaL.A., Peña-RodriguezL.M., Molina-SalinasG.M., VallejosJ., ColladoI.G., SimirgiotisM.J. (2014) Further mulinane and azorellane diterpenoids isolated from Mulinum crassifolium and Azorella compacta.Molecules, 19, 3898–3908.
13.
NewtonS., LauC., GurchaS., BesraG., WrightC. (2002) The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis.Journal of Ethnopharmacology, 79, 57–67.
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16.
Clinical, and Laboratory Standards Institute (CLSI). (2009) Performance standards for antimicrobial susceptibility testing. Approved standard M100-S19. 19th informational supplement. In Clinical and Laboratory Standards Institute.Wayne, PA.
