Two New Anthraquinones from the Roots of Prismatomeris connata

Abstract

Two new anthraquinones, 4-hydroxy-1,2,3-trimethoxy-7-hydroxymethylanthracene-9,10-dione (1) and 1,2,3-trimethoxy-7-hydroxymethylanthracene-9,10-dione (2), were isolated from the roots of Prismatomeris connata, a Chinese medicinal herb. Their structures were elucidated by spectroscopic analysis. Compound 1 exhibited cytotoxicity against a panel of H1229, HTB179, A549 and H520 lung tumor cell lines with IC₅₀ values ranging from 12.3 to 20 μM.

Keywords

Prismatomeris connata Anthraquinones Cytotoxicity

References

Ruan

Y.Z.

(1988) Notes on the genus Prismatomeris Thw. (Rubiaceae) of China. Journal of Systematics and Evolution, 26, 443–449.

Anonymous. (1992) Compendium of Chinese Traditional Herbal Drugs, People's Health Press: Beijing, 2, 772.

D.J.

, Pang

Z.H.

, Bi

N.J.

(1981) Studies on constituents of Prismatomeris tetrandra (Roxb.) K Schum. Acta Pharmacologica Sinica, 16, 631–633.

Jiang

J.S.

, Feng

Z.M.

, Zhang

P.C.

(2005) Chemical constituents from root of Prismatomeris tetrandra. Chinese Journal of Chinese Materia MedicamL 30, 1751–1753.

Feng

Z.M.

, Jiang

J.S.

, Zhang

P.C.

(2005) Anthraquinones from the roots of Prismatomeris tetrandra. Chemical and Pharmaceutical Bulletin, 53, 1330.

Hao

, Feng

S.X.

, Qiu

S.X.

, Chen

(2011) Anthraquinone glycosides from the roots of Prismatomeris connata. Chinese Journal of Natural Medicines, 9, 42–45.

Feng

S.X.

, Hao

, Chen

, Qiu

S.X.

(2011) A new anthraquinone and two new tetrahydroanthraquinones from the roots of Prismatomeris connata. Helvetica Chimica Acta, 94, 1843–1849.

Feng

S.X.

, Hao

(2012) Iridoid and phenolic glycosides from the roots of Prismatomeris connata. Natural Product Communications, 7, 561–562.

Wang

C.X.

, Ding

, Feng

S.X.

, Guan

, Zhang

X.P.

, Du

, Di

Y.T.

, Chen

(2015) Seven new tetrahydroanthraquinones from the root of Prismatomeris connata and their cytotoxicity against lung tumor cell growth. Molecules, 20, 22565–22577.

10.

Feng

S.X.

, Guan

, Chen

, Du

(2012) In vitro activities of 3-hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone against non-small cell lung carcinoma. Archives of Pharmacal Research, 35, 1251–1258.

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