Acidiscalide,A New Glycosylated Macrolide from the Marine Actinomycete Streptomyces Acidiscabies

Abstract

A new macrolide named acidiscalide (2), and a known protein synthesis inhibitor, cycloheximide (1), were isolated from the culture broth of a strain of actinomycete, Streptomyces acidiscabies, coded SCTA0002 collected from the coast of Okinawa. The structure of acidiscalide (2) was elucidated to be a glycosylated macrolide having a 24-membered ring on the basis of spectroscopic analysis. Although the stereochemistry could not be determined due to decomposition in the course of the study, it was confirmed that acidiscalide (2) possessed a new molecular scaffold.