An antibacterial assay-guided isolation of the crude ethyl acetate extract from Ficus foveolata stems afforded four compounds, including a tetrahydronaphthalene lignanamide, foveolatamide (1), together with two known lignanamides, flavifloramide B (2) and N-trans-grossamide (3), and a known phenolic amide, N-trans-feruloyltyramine (4). The structures of these compounds were established on the basis of NMR spectroscopic and MS techniques. Among the isolated compounds, only 1 showed satisfactory antibacterial activities against Streptococcus pyogenes, with an MIC and MBC value of 45 μM. This is the first report of these four compounds from the stems of F. foveolata.
ChaudharyLB, SudhakarJV, KumarA, BajpaiO, TiwariR, MurthyGVS. (2012) Synopsis of the genus Ficus L. (Moraceae) in India. Taiwania, 57, 193–216.
2.
SuksriS, PremcharoenS, ThawatphanC, SangthongprowS. (2005) Ethnobotany in Bung Khong Long Non-Hunting Area, Northeast Thailand. Kasetsart Journal Natural Science, 39, 519–33.
3.
KunwarRM, BussmannRW. (2006) Ficus (Fig) species in Nepal: a review of diversity and indigenous uses. Lyonia, 11, 85–97.
4.
MeerungrueangW, PanichayupakaranantP. (2014) Antimicrobial activities of some Thai traditional medical longevity formulations from plants and antibacterial compounds from Ficus foveolata. Pharmaceutical Biology, 52, 1104–1109.
5.
DinAUD, UddinG, HussainN, KhanA, KhanI, ShadAA, ChoudharyMI. (2013) Bioassay-guided isolation of new antitumor agent from Ficus faveolata (Wall. ex Miq.). Cancer Science & Therapy, 5, 404–408.
6.
SomwongP, SuttisriR, BuakeawA. (2013) New sesquiterpenes and phenolic compound from Ficus foveolata. Fitoterapia, 85, 1–7.
7.
SermboonpaisarnT, SawasdeeP. (2012) Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata. Fitoterapia, 83, 780–784.
8.
WuY, ZhengCJ, DengXH, QinLP. (2013) Two new bis-alkaloids from the aerial part of Piper flaviflorum. Helvetica Chimica Acta, 96, 951–955.
9.
KingRR, CalhounLA. (2005) Characterization of cross-linked hydroxycinnamic acid amides isolated from potato common scab lesions. Phytochemistry, 66, 2468–2473.
10.
SecaAML, SilvaAMS, SilvestreAJD, CavaleiroJAS, DominguesFMJ, NetoCP. (2001) Lignanamides and other phenolic constituents from the bark of kenaf (Hibiscus cannabinus). Phytochemistry, 58, 1219–1223.
11.
XieLW, AtanasovAG, GuoDA, MalainerC, ZhangJX, ZehlM, GuanSH, HeissEH, UrbanE, DirschVM, KoppB. (2014) Activity-guided isolation of NF-kB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller. Journal of Ethnopharmacology, 152, 470–477.
12.
TanakaH, YatsuhashiS, YasudaT, SatoM, SakaiE, XiaoC, MurataH, MurataJ. (2009) A new amide from the leaves and twigs of Litsea auriculata. Jounal of Natural Medicines, 63, 331–334.
13.
MaCY, LiuWK, CheCT. (2002) Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. Journal of Natural product, 65, 206–209.
14.
YokozawaT, TanakaT, KimuraT. (2001) Examination of the nitric oxide production-suppressing component in Tinospora tuberculata. Biological and Pharmaceutical Bulletin, 24, 1153–1156.
15.
LiWJ, ChengXL, LiuJ, LinRC, WangGL, DuSS, LiuZL. (2012) Phenolic compounds and antioxidant activities of Liriope muscari. Molecules, 17, 1797–1808.
16.
EfdiM, OhguchiK, AkaoY, NozawaY, KoketsuM, IshiharaH. (2007) N-trans-feruloyltyramine as a melanin biosynthesis Inhibitor. Biological and Pharmaceutical Bulletin, 30, 1972–1974.
17.
NCCLS. (2008) Performance standards for antimicrobial susceptibility testing. Ninth informational supplement. NCCLS document M100-S9. Wayne (PA): National Committee for Clinical Laboratory Standard.
