A new cyclic tetrapeptide, asperterrestide B (1), and 11 known compounds (2–12) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162. The structure of 1 was elucidated by spectroscopic analysis, and the absolute configuration of 1 was determined by Mosher ester and Marfey's methods. Compounds 4, 6, and 8 had potent antifouling activity against larvae of the barnacle Balanus amphitrite, with EC50 values of 17.1±1.2, 11.6±0.6, and 17.1±0.8 μg·mL-1, respectively.
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