Isolation and Characterization of Antiangiogenesis Compounds from the Fungus Aspergillus terreus Associated with Apostichopus japonicus Using Zebrafish Assay

Abstract

Three compouds, (+)-butyrolactone IV (1), butyrolactone I (2) and terrelactone A (3) were isolated from the fungus Aspergillus terreus associated with Apostichopus japonicus from the Yellow Sea in China; their structures were elucidated by spectral methods. Compounds 1 and 2 were shown to have moderate antiangiogenesis activity when tested using the zebrafish assay. This is the first report of butyrolactones with antiangiogenesis activity.