Bioactive Oleanane Glycosides from Polyscias duplicata from the Madagascar Dry Forest [1]

Abstract

As part of the International Cooperative Biodiversity Group (ICBG) program, in a search for antiproliferative compounds, an ethanol extract of Polyscias duplicata was investigated due to its antiproliferative activity against the A2780 human ovarian cell cancer line (IC₅₀ 6 μg/mL). Seven known oleanane glycosides, 3β-[(α-L-arabinopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (1, IC₅₀ 8 μM), 3β-[(α-L-arabinopyranosyl)oxy]-16α,23-dihydroxyolean-12-en-18-oic acid (2, IC₅₀ 13 μM), 3β-[(O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]–16α-hydroxyolean-12-en-28-oic acid (3, IC₅₀ 7 μM), 3β-[(O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]-16α-hydroxyolean-12-en-28-oic acid (4, IC₅₀ 2.8 μM), 3β-[(O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl)oxy]–23-hydroxyolean-12-en-28-oic acid (5, IC₅₀ 10 μM), 3β-[(O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (6, IC₅₀ 3.4 μM), and 3β-[(α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (7, IC₅₀ 3.4 μM) were isolated, and their structures determined using spectroscopic methods.