Synthesis of Chiral Hexasubstituted Cyclohexanediol,a Key Intermediate for the Synthesis of Verticillol,from (+)-Dihydrocarvone;Attempted Cyclization to 12-Membered Carbocycle in Verticillol using RCM Reaction
Free accessResearch articleFirst published online April, 2015
Synthesis of Chiral Hexasubstituted Cyclohexanediol,a Key Intermediate for the Synthesis of Verticillol,from (+)-Dihydrocarvone;Attempted Cyclization to 12-Membered Carbocycle in Verticillol using RCM Reaction
A cyclohexane derivative with three chiral centers, a key intermediate for the synthesis of a diterpene verticillol, was prepared starting from (+)-dihydrocarvone. A further challenge to cyclize to a 12-membered carbocycle was attempted, although the products were dimeric derivatives presumably due to an undesirable conformation of the substrate.
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