Free accessResearch articleFirst published online 2015-2
Anthocephaline,a New Indole Alkaloid and Cadambine,a Potent Inhibitor of DNA Topoisomerase IB of Leishmania donovani (LdTOP1LS),Isolated from Anthocephalus cadamba
Chemical investigation of the stem bark of Anthocephalus cadamba has resulted in the isolation of anthocephaline (1), a new indole alkaloid, along with strictosamide (2), vincosamide (3) and cadambine (4). The structures of the isolated alkaloids (1-4) were established by detailed 2D NMR spectral analysis. Cadambine (4) exhibited potent DNA topoisomerase IB inhibitory activity.
UmachigiSP, KumarGS, JayaveeraKN, KishoreDVK, Ashok KumarCK, DhanpalR. (2007) Antimicrobial wound healing and antioxidant activities of Anthocephlous cadamba. African Journal of Traditional, Complementary and Alternative Medicines, 4, 481–487.
2.
AhmedF, RahmanS, ShamedN, HossainM, BiswasA, SarkarS, BannaH, KhatunMA, ChowdhuryMH, RahmatullahM. (2011) Evaluation of Neolamarckia cadamba (Roxb.) Bosser leaf extract on glucose tolerance in glucose-induced hyperglycemic mice. African Journal of Traditional, Complementary and Alternative Medicines, 8, 79–81.
3.
ChandelM, SharmaU, KumarN, SinghB, KaurS. (2012) Antioxidant activity and identification of bioactive compounds from leaves of Anthocephalous cadamba by ultra performance liquid chromatography/ electrospray ionization quadrupole time of flight mass spectrometry. Asian Pacific Journal of Tropical Medicine, 5, 977–985.
4.
QureshiAK, MukhtarMR, HirasawaY, HosoyaT, NugrohoAE, MoritaH, ShirotaO, MohamadK, HamidA, HadiA, LitaudonM, AwangK. (2011) . Neolamarckines A and B new indole alkaloids from Neolamarckia cadamba. Chemical and Pharmaceutical Bulletin, 59, 291–293.
5.
SahuNP, KoikeK, JiaZ, AchariB, BanerjeeS, NikaidoT, (1999) Structure of two novel isomeric triterpenoid saponins from Anthocephalous cadamba, Magnetic Resonance in Chemistry, 37, 837–842.
6.
SanadhyaI, BhotM, VargheseJ, ChandraN. (2012) Antidiabetic activity of leaves of Anthocephalous indicus A. Rich in alloxon induced diabetic rats. International Journal of Phytomedicine, 4, 511–518.
7.
ErdelmeierCAJ, WrightAD, OrjalaJ, BaumgartnerB, RaliT, SticherO. (1990) New indole alkaloid glycosides from Nauclea orientalis. Planta Medica, 57, 149–152.
8.
HandaSS, BorrisRP, CordellGA. (1983) NMR spectral analysis of cadambine from Anthocephalus chinensis. Journal of Natural Products, 46, 325–330
9.
ShigemoriH, KagataT, IshiyamaH, MorahF, OhsakiA, KobayashiJ. (2003) Naucleamides A-E, new monoterpene indole alkaloids from Nauclea latifolia. Chemical and Pharmaceutical Bulletin, 51, 58–61.
10.
ChowdhuryS, MukherjeeT, SenguptaS, ChowdhurySR, MukhopadhyayS, MajumderHK. (2011) Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase. Molecular Pharmacology, 80, 694–703.
11.
KumarA, ChowdhurySR, ChakrabartiT, MajumdarHK, JhaT, MukhopadhyayS. (2014) A new ellagic acid glycoside and DNA topoisomerase IB inhibitory activity of saponins from Putranjiva roxburghii. Natural Product Communications, 9, 675–677.
