The present study evaluated the antidiabetic effect of osajin and pomiferin from the osajin orange in normal and streptozotocin-induced diabetic rats. Pomiferin in the streptozotocin-induced diabetic effects showed significant hypoglycemic activity for 14 days significantly decreased the serum glucose, triglyceride while it increased the serum insulin in diabetic rats but not in normal rats (p < 0.05; at doses of 100 and 300mg/kg for 14 days). Pomiferin showed potential in anti-diabetic effects compared to osajin. It also has no effects on C-peptide (ECLIA). Further structure-activity relationships of aromatic position 3 on ring B from osajin and pomiferin will be reported in due course.
HoornD.E., NijveldtR.J., Van LeeuwenP.A., HofmanZ., RabetLM’, De BontD.B., Van NorrenK. (2002) Accurate prediction of xanthine oxidase inhibition based on the structure of flavonoids. European Journal of Pharmacology, 13, 111–118.
NishinoH., TokudaH., SatomiY., MasudaM., OsakaY., YogosawaS., WadaS., MouX.Y., TakayasuJ., MurakoshiM., JinnnoK., YanoM. (2004) Cancer prevention by antioxidants. Biofactors, 22, 57–61.
4.
HošekJ., TonioloA., NeuwirthO., BolegoC. (2013) Prenylated and geranylated flavonoids increase production of reactive oxygen species in mouse macrophages but inhibit the inflammatory response. Journal of Natural Products, 76, 1586–1591.
5.
YangR., HanwellH., ZhangJ., TsaoR., MecklingK.A. (2011) Antiproliferative activity of pomiferin in normal (MCF-10A) and transformed (MCF-7) breast epithelial cells. Journal of Agricultural and Food Chemistry, 59, 13328–13336.
6.
SezikE., AslaM., YesiladaE., ItoS. (2005) Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques. Life Sciences, 76, 1223–1238.
7.
GiulianoD., MonacheR.S., AlbertoV., BrunoB., BarbaraM., GabriellaP., CleofeP., EnricoC. (1994) Two isoflavones and a flavone from the fruits of Maclura pomifera. Phytochemistry, 37, 893–898.
8.
EidiA., EidiM., DarziR. (2009) Antidiabetic effect of Olea europaea L. in normal and diabetic rats. Phytotherapy Research, 23, 347–350.
9.
RifaiN., BachorikP.S., AlbersJ.J. (1999) Lipids, lipoproteins and apolipoproteins. In: BurtisC.A., AshwoodE.R. (Eds) Tietz textbook of clinical chemistry. 3rd ed. Philadelphia: WB Saunders, pp. 809–861.
