Four new cucurbitane-type triterpene glycosides, charantosides D-G (1–4) were isolated from a methanol extract of Momordica charantia fruits. The structures of these compounds were determined by chemical and spectroscopic methods to be (19R)-5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol 3-O-β-D-glucopyranoside, (19R)-5β,19-epoxy-25-methoxycucurbita-6,23-diene-3β,19-diol 3-O-β-D-allopyranoside, 7β-methoxycucurbita-5,23E,25-triene-3β-ol 3-O-β-D-allopyranoside, and 3β,7β-dihydroxycucurbita-5,23E,25-triene-19-al 3-O-β-D-allopyranoside.
GroverJ.K., YadavS.P. (2004) Pharmacological actions and potential uses of Momordica charantia: a review. Journal of Ethnopharmacology, 93, 123–132.
2.
ChenJ., TianR., QiuM., LuL., ZhengY., ZhangZ. (2008) Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry, 69, 1043–1048.
3.
NhiemN.X., KiemP.V., MinhC.V., BanN.K., CuongN.X., TungN.H., MinhHl, HaD.T., TaiB.H., QuangT.H., NgocT.M., KwonY.I., JangH.D., KimY.H. (2010) α-Glucosidase inhibition properties of cucurbitane-type triterpene glycosides from the fruits of Momordica charantia. Chemical and Pharmaceutical Bulletin, 58, 720–724.
4.
NhiemN.X., KiemP.V., ChauV.M., BanN.K., CuongN.X., HaL.M., TaiB.H., QuangT.H., TungN.H., KimY.H. (2010) Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia. Magnetic Resonance in Chemistry, 48, 392–396.
5.
LiaoY.W., ChenC.R., KuoY.H., HsuJ.L., ShihW.L., ChengH.L., HuangT.C., ChangC.I. (2012) Cucurbitane-type triterpenoids from the fruit pulp of Momordica charantia. Natural Product Communications, 7, 1575–1578.
6.
YasudaM., IwamotoM., OkabeH., YamauchiT. (1984) Structures of momordicines I, II and III, the bitter principles in the leaves and vines of Momordica charantia L. Chemical and Pharmaceutical Bulletin, 32, 2044–2047.
7.
ChippsE.S., JayiniR., AndoS., ProtzmanA.D., MuhiM.Z., MottalebM.A., MalkawiA., IslamM.R. (2012) Cytotoxicity analysis of active components in bitter melon (Momordica charantia) seed extracts using human embryonic kidney and colon tumor cells. Natural Product Communications, 7, 1203–1208.
8.
ChangC.I., ChenC.R., LiaoY.W., ChengH.L., ChenY.C., ChouC.H. (2006) Cucurbitane-type triterpenoids from Momordica charantia. Journal of Natural Products, 69, 1168–1171.
