A new pterocarpan, aeschynocarpin (1), and the known pterocarpan 2-methoxymedicarpin (2) were isolated for the first time from Aeschynomene fascicularis (Fabaceae) and their structures elucidated by means of spectroscopic {UV/Vis, IR, and NMR (1H, 13C, COSY, HMQC, and HMBC)} and mass spectrometric (EI-MS and HRCIMS) techniques. Both compounds were tested in vitro for their cytotoxic and antiproliferative activities against a panel of cancer cell lines. This is the first report on the presence of pterocarpans in the genus Aeschynomene.
Caamal-FuentesE., Torres-TapiaL.W., Simá-PolancoP., Peraza-SánchezS.R., Moo-PucR. (2011) Screening of plants used in Mayan traditional medicine to treat cancer-like symptoms. Journal of Ethnopharmacology, 135, 719–724.
2.
PueppkeS.G., VanEttenH.D. (1975) Identification of three new pterocarpans (6a,11a-dihydro-6H-benzofuro[3,2-c][l]benzopyrans) from Pisum sativum infected with Fusarium solani f. sp. pisi. Journal of the Chemical Society, Perkin Transactions 1, 10, 946–948.
3.
ChinY.W., MdeeL.K., MbwamboZ.H., MiQ., ChaiH.B., CraggG.M., SwansonS.M., KinghornA.D. (2006) Prenylated flavonoids from the root bark of Berchemia discolor, a Tanzanian medicinal plant. Journal of Natural Products, 69, 1649–1652; (b) Rahman A, Choudhary MI, Thomsen WJ. (2001) Bioassay techniques for drug development. In Manual of Bioassay Techniques for Natural Products Research, Harwood Academic Publishers, Netherlands, pp. 34–35; (c) Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren JT, Bokesch H, Kenney S, Boyd MR. (1990) New colorimetric cytotoxicity assay for anticancer-drug screening. The Journal of the National Cancer Institute, 4, 1107–1112.