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Abstract

A new ergosterol, 15β-hydroxyl-(22E,24R)-ergosta-3,5,8,22-tetraen-one (1), along with three known ergosterols, two known cytochalasins, and two known azapholines were isolated from Chaetomium globosum Z1. The structures of these compounds were elucidated on the basis of spectroscopic methods (HR-ESI-MS, 1D NMR, and 2D NMR). Compound 6 showed significant cytotoxic activity against A-549 and MG-63 cell lines with IC₅₀ values of 6.96 and 1.73 μg/mL, respectively.

Keywords

Constituents Chaetomium globosum Ergosterol

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Chemical Constituents from an Endophytic Fungus Chaetomium Globosum Z1

Abstract

Keywords

References

Supplementary Material