A new 16-membered macrolide named aspergillide D (1), along with six known compounds, including two polyketones (2–3) and four alkaloids (4–7), were isolated from the culture broth of a marine-derived fungus Aspergillus sp. SCSGAF 0076. The structure of 1 was elucidated on the basis of NMR and mass spectra. Compound 5 showed an obvious inhibitory effect on influenza virus strains H1N1 and H3N2.
AinsworthT.D., ThurberR.V., GatesR.D. (2010) The future of coral reefs: a microbial perspective. Trends in Ecology & Evolution, 25, 233–240.
2.
(a) HarvellC., KimK., BurkholderJ., ColwellR., EpsteinP.R., GrimesD., HofmannE., LippE., OsterhausA., OverstreetR.M. (1999) Emerging marine diseases–climate links and anthropogenic factors. Science, 285, 1505–1510;(b) Shnit-Orland M, Kushmaro A. (2009) Coral mucus-associated bacteria: a possible first line of defense. FEMS Microbiology Ecology, 67, 371–380; (c) Bhatnagar I, Kim SK. (2010) Immense essence of excellence: marine microbial bioactive compounds. Marine Drugs, 8, 2673–2701; (d) Karna Radjasa O. (2004) Marine invertebrate-associated bacteria in coral reef ecosystems as a new source of bioactive compounds. Journal of Coastal Development, 7, 65–70.
3.
(a) YadaH., SatoH., ToshimaH., DeuraM., IchiharaA. (2001) (-)-Semivioxanthin, a new abscisic active compound against Hinoki cypress leaves isolated from Cryptosporiopsis abietina. Bioscience Biotechnology and Biochemistry, 65, 484–486;(b) Fang JJ, Ye G, Chen WL, Zhao WM. (2008) Antibacterial phenolic components from Eriocaulon buergerianum. Phytochemistry, 69, 1279–1286; (c) Belofsky GN, Jensen PR, Renner MK, Fenical W. (1998) New cytotoxic sesquiterpenoid nitrobenzoyl esters from a marine isolate of the fungus Aspergillus versicolor. Tetrahedron, 54, 1715–1724; (d) Wu QX, Crews MS, Draskovic M, Sohn J, Johnson TA, Tenney K, Valeriote FA, Yao XJ, Bjeldanes LF, Crews P. (2010) Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola. Organic Letters, 12, 4458–4461.
4.
(a) FrancoC.M.M., GandhiJ.N., ChatterjeeS., GanguliB.N. (1987) Swalpamycin, a new macrolide antibiotic. I. Taxonomy of the producing organism, fermentation, isolation and biological activity. Journal of Antibiotics, 40, 1361–1367;(b) Park JS, Yang HO, Kwon HC. (2009) Aldgamycin I, an antibacterial 16-membered macrolide from the abandoned mine bacterium, Streptomyces sp KMA-001. Journal of Antibiotics, 62, 171–175; (c) Ditrich K, Bube T, Stürmer R, Hoffmann RW. (1986) Total synthesis of mycinolide V, the aglycone of a macrolide antibiotic of the mycinamycin series. Angewandte Chemie International Edition in English, 25, 1028–1030; (d) Asolkar RN, Maskey RP, Helmke E, Laatsch H. (2002) Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp B7064. Journal of Antibiotics, 55, 893–898.
5.
(a) YangS.W., ChanT.M., TerraccianoJ., LoebenbergD., PatelM., ChuM. (2005) Structure elucidation of Sch 725674 from Aspergillus sp. Journal of Antibiotics, 58, 535–538; (b) Kito K, Ookura R, Yoshida S, Namikoshi M, Ooi T, Kusumi T. (2008) New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus. Organic Letters, 10, 225-228.
6.
(a) ChengH.M., WanJ.T., LinM.I., LiuY.X., LuX.Y., LiuJ.S., XuY, ChenJ.X., TuZ.C., ChengY.E., DingK. (2012) Design, synthesis, and in vitro biological evaluation of 1H–1,2,3-triazole-4-carboxamide derivatives as new anti-influenza A agents targeting virus nucleoprotein. Journal of Medicinal Chemistry, 55, 2144–2153;(b) Bao J, Zhang XY, Xu XY, He F, Nong XH, Qi SH. (2013) New cyclic tetrapeptides and asteltoxins from gorgonian-derived fungus Aspergillus sp. SCSGAF 0076. Tetrahedron, 69, 2113–2117.
