Synthesis of a Key Intermediate,10-Acetyl-7-( t -butyldiphenylsilyloxymethyl)-4-methylbicyclo[5.3.0]dec-4-en-1-ol,in the Synthesis of Pseudolaric Acid A
Free accessResearch articleFirst published online July, 2013
Synthesis of a Key Intermediate,10-Acetyl-7-( t -butyldiphenylsilyloxymethyl)-4-methylbicyclo[5.3.0]dec-4-en-1-ol,in the Synthesis of Pseudolaric Acid A
10-Acetyl-7-(t-butyldiphenylsilyloxymethyl)-4-methylbicyclo[5.3.0]dec-4-en-1-ol was synthesized by aldol cyclization to a five-membered ring, epoxidation, samarium diiodide-induced ring opening, and the RCM reaction to the seven-membered carbocycle. This method has succeeded in constructing the desired stereochemistry in the synthesis of pseudolaric acid A.
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