Sage Journals: Discover world-class research

Abstract

A new sulfated triterpeniod saponin, 3-O-sulfooleanolic acid 28-O-[β-glucopyranosyl-(1→3)]-[β-glucopyranosyl-(1→6)]-β-glucopyranosyl ester (1), along with three known Δ⁷-sterols: stigmast-7-en-3β-ol (2), stigmast-7-en-3-O-β-D-glucopyranoside (3) and stigmast-7-en-3-on (4) were isolated from the roots of Gypsophila trichotoma Wend. (Caryophyllaceae). Their structures were elucidated by chemical and spectral methods. Compound 1 caused concentration-dependent inhibition of malignant cell proliferation against different human tumor cell lines.

Keywords

Gypsophila trichotoma Sulfated saponin

References

Jordanov

(1966) Flora Republicae Popularis Bulgaricae. Aedibus Acad. Sci. Bulgaricae, Sofia, 388.

(a) Krasteva

, Popov

, Pencheva

, Balabanova

, Nikolov

(2008) Phytochemical study of Gypsophila trichotoma Wend. (Caryophyllaceae). Quimica Nova, 31, 1125–1126;(b) Krasteva I, Yotova M, Popov I, Zdraveva P, Nikolov S. (2009) Phytochemical study of leaves and roots of Gypsophila trichotoma Wend. using gas chromatography-mass spectrometry. Pharmacia, 56, 3–6; (c) Krasteva I, Jenet-Siems K, Kaloga M, Nikolov S. (2009) 3-O-Sulfo-triterpenoid saponins from Gypsophila trichotoma Wend. Zeitschrift für Naturforschung B, 64, 319–322; (d) Yotova M, Krasteva I, Jenett-Siems K, Zdraveva P, Nikolov S. (2012) Triterpenoids in Gypsophila trichotoma Wend. Phytochemistry Letters, 5, 752–755; (e) Yotova M, Krasteva I, Nikolov S. (2012) Triterpenoid saponins from genus Gypsophila L. (Caryophyllaceae). Koh R. Tay I. (Eds), In Saponins: Properties, Applications and Health Benefits Chapters, Nova Science Publishers, New York, USA, 99–122.

(a) Kojima

, Sato

, Hatano

, Ogura

(1990) Sterol glucosides from Prunela vulgaris. Phytochemistry. 29, 2351–2355; (b) Saied S, Begum S. (2004) Phytochemical studies of Berberis vulgaris. Chemistry of Natural Compounds, 40, 137–140; (c) Mehta BK, Mehta D, Verma M. (2005) Novel steroids from the seeds of Centratherum anth elminticum. Natural Product Research, 19, 435–442.

(a) Tori

, Seo

, Shimaoka

, Tomita

(1974) Carbon-13-NMR spectra of olean-12-enes. Full signal assignments including quaternary carbon signals assigned by use of indirect 13C, 1H spin couplings. Tetrahedron Letters, 48, 4227–4230;(b) Zhao J, Nakamura N, Hattori M, Yang XW, Ufmatsu K, Qui MH. (2004) New triterpenoid saponins from the roots of Sinocrassula asclepiadea. Chemical & Pharmaceutical Bulletin, 52, 230–237; (c) Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55–63; (d) Konstantinov SM, Eibl H, Berger MR (1999) BCR-ABL influences the antileukaemic efficacy of alkylphosphocholines. British Journal of Haematology, 107, 365–380.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.09 MB

A New Sulfated Triterpene Saponin from Gypsophila trichotoma

Abstract

Keywords

References

Supplementary Material