A new homoisoflavanone, (3R)-5,7-dihydroxy-8-methyl-3-(2′-hydroxy-4′-methoxybenzyl)-chroman-4-one (1), was isolated from the 95% ethanol extract of the rhizomes of Polygonatum cyrtonema. The structure of 1 was determined by spectroscopic methods, especially 2D NMR techniques. Quantum chemical TD DFT calculations of the theoretical ECD spectrum of 1 allowed assignment of the absolute configuration as 3R.
Jiangsu New Medical College. (1977) Chinese Materia Medica Dictionary, 1st ed. Shanghai Science and Technology Press, Shanghai, vol. 2, pp 2041–2044.
2.
WangSY, YuQJ, BaoJK, LiuB., (2011) Polygonatum cyrtonema lectin, a potential antineoplastic drug targeting programmed cell death pathways. Biochemical and Biophysical Research Communications, 406, 497–500.
3.
LiuXX, WanZJ, ShiL, LuXX. (2011) Preparation and antiherpetic activities of chemically modified polysaccharides from Polygonatum cyrtonema Hua. Carbohydrate Polymers, 83, 737–742.
4.
ZhouCX, ZouL, MoJX, WangXY, YangB, HeQJ, GanLS. (2013) Homoisoflavonoids from Ophiopogon japonicus. Helvetica Chimica Acta, in press.
5.
ZhangH, YangF, QiJ, SongXC, HuZF, ZhuDN, YuBY. (2010) Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes. Journal of Natural Products, 73, 518–522.
6.
ChangJM, ShenCC, HuangYL, ChienMY, OuJC, ShiehBJ, ChenCC. (2002) Five new homoisoflavonoids from the tuber of Ophiopogon japonicus. Journal of Natural Products, 65, 1731–1733.
7.
MutanyattaJ, MatapaBG, ShushuDD, AbegazBM. (2003) Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids. Phytochemistry, 62, 797–804.
8.
AdinolfiM, BaroneG, CorsaroMM, MangoniL, LanzettaR, ParrilliM., (1988) Absolute configuration of homoisoflavanones from Muscari species. Tetrahedron, 44, 4981–4988.
9.
AmschlerG, FrahmAW, HatzelmannA, KilianU, Mueller-DobliesD, Mueller-DobliesU. (1996) Constituents of Veltheimia viridifolia. I. Homoisoflavanones of the bulbs. Planta Medica, 62, 534–539.
