A new scalarane sesterterpenoid, hippospongide C (1), along with four previously reported known scalarane–type sesterterpenes (2–5), were isolated from a sponge Hippospongia sp. The structure of 1 was elucidated on the basis of its spectroscopic data and comparison of its NMR data with those of known analogues. The cytotoxicity of 1–5 against DLD-1, HCT-116, T-47D and K562 cell lines was evaluated. The results showed that compound 4 exhibited potent activity against DLD-1, HCT-116 and T-47D cell lines with IC50 values of 1.3–2.0 μg/mL. Furthermore, metabolites 1–5 were also found to exhibit significant cytotoxicity towards the K562 cell line with IC50 values of 0.01–2.9 μg/mL.
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