Trichodermaerin (1), a novel diterpenoid lactone, together with the known compound, harziandione (2) were isolated from the culture broth of the fungus Trichoderma erinaceum associated with the sea star Acanthaster planci. Their structures were determined by analysis of the NMR and MS data. 1 was the Baeyer-Villiger monooxygenase catalyzed oxidation product of 2. Compound 2 did not show cytotoxic activities against various cancer cell lines.
LanWJ, ZhaoY, XieZL, LiangLZ, ShaoWY, ZhuLP, YangDP, ZhuXF, LiHJ. (2012) Novel sorbicillin analogues from the marine fungus Trichoderma sp. associated with the seastar Acanthaster planci. Natural Product Communications, 7, 1337–1340.
2.
GhisalbertiEL, HocklessDCR, RowlandC, WhiteAH. (1992) Harziandione, a new class of diterpene from Trichoderma harzianum. Journal of Natural Products, 55, 1690–1694.
3.
PazminoDET, DudekHM, FraaijeMW. (2010) Baeyer-Villiger monooxygenases: recent advances and future challenges. Current Opinion in Chemical Biology, 14, 138–144.
