Two new dihydroflavonol derivatives, macarecurvatins A and B, have been isolated from the leaves of Macaranga recurvata(Euphorbiaceaae), along with the known compounds diisoprenylaromadendrin, glyasperin A and broussoflavonol F. The structures of the new compounds were determined on the basis of spectroscopic evidence. Upon cytotoxic evaluation against P-388 cells, macarecurvatin B showed strong activity with an IC50 of 0.83 μM.
SyahYM, HakimEH, AchmadSA, HanafiM, GhisalbertiEL. (2009) Isoprenylated flavanones and dihydrochalcones from Macaranga trichocarpa. Natural Product Communications, 4, 63–67.
2.
TanjungM, HakimEH, MujahidinD, HanafiM, SyahYM. (2009) Macagigantin, a farnesylated flavonol from Macaranga gigantea. Journal of Asian Natural Products Research, 11, 929–932.
3.
SyahYM, GhisalbertiEL. (2010) Phenolic derivatives with an irregular sesquiterpenyl side chain from Macaranga pruinosa. Natural Product Communications, 5, 219–222.
SyahYM, GhisalbertiEL. (2012) More phenolic derivatives with an irregular sesquiterpenyl side chain from Macaranga pruinosa. Natural Products Journal, 2, 45–49.
6.
MeragelmanKM, McKeeTC, BoydMR. (2001) Anti-HIV prenylated flavonoids from Monotes africanus. Journal of Natural Products, 64, 546–548.
7.
ZengL, FukaiT, NomuraT, ZhangY-Y, LouZ-C, (1992) Phenolic constituents of Glycyrrhiza species. 8. Four new prenylated flavonoids, glyasperins A, B, C, and D from the roots of Glycyrrhiza aspera. Heterocycles, 34, 575–587.
NonakaGI, GotoY, KinjoJE, NoharaT, NishiokaI. (1987) Tannins and related compounds. Part LII: Studies on the constituents of the leaves of Thujopsis dolabrata SIEB. et ZUCC. Chemical and Pharmaceutical Bulletin, 35, 1105–1108.
10.
SahidinHakim EH, JuliawatyLD, SyahYM, DinLB, GhisalbertiEL, LatipJ, SaidIM, AchmadSA. (2005). Cytotoxic properties of oligostilbenoids from the tree bark of Hopea dryobalanoides. Zeitschrift für Naturforschung, 60C, 723–727.
