Phytochemical studies of the leaves and rhizomes of Paraboea pa niculata (Gesneriaceae) are reported for the first time. Three phenylethanoid glycosides were isolated and characterized as 3,4-dihydroxyphenethyl-(3″-O-β-D-apiofuranosyl)-β-D-glucopyranoside, calceoralarioside E, and acteoside. These isolates exhibited weak cytotoxic activity against the K-562 cell line with a 50% of cell killing rate of 40.18 μM, 27.05 μM, and 27.24 μM, respectively. In the DPPH free radical scavenging assay, their IC50 values were determined as 75.89 μM, 25.00 μM, and 26.04 μM, respectively.
SoepadmoA. (1998) Limestone, quartzite and ultramatic vegetation. In The Encyclopedia of Malaysia Plants. Archipelago Press, Singapore, 26–27.
2.
TanHY. (2008) Ethnomedicinal approach in screening of cytotoxic phytochemicals from local medicinal plants [dissertation]. University Tunku Abdul Rahman, Malaysia.
3.
ToiLR. (2008) Ethnomedicinal approach in screening of cytotoxicity and DPPH radical scavenging activities of local medicinal plants [dissertation]. University Tunku Abdul Rahman, Malaysia.
4.
WangX, PengY, XuL, XiaoW, XiaoP, LiuY. (2009) Triterpenes and triterpene glycosides from aerial part of Paraboea glutinosa. Zhong Guo Zhong Yao Za Zhi, 34, 1228–1230.
5.
TanHY. (2011) Evaluation of fingerprint profile using chromatographic techniques of bioactive herbal phytochemicals isolated from Paraboea paniculata [dissertation]. University Tunku Abdul Rahman, Malaysia.
6.
ZhengXK, LiJ, FengWS, BiYF, JiCR. (2003) Isolation and structural identification of phenylethanoid glycosides from Corallodiscus flabellate. Acta Pharmaceutica Sinica, 38, 116–119.
7.
DamtoftS, FranzykH, JensenSR, NielsenBJ. (1993) Iridoids and verbascosides in Retzia. Phytochemistry, 34, 239–243.
8.
KitagawaS, TsukamotoH, HisadaS, NishebeS. (1984) Studies on the Chinese crude drug “Forsythiae Fructus.” VII. A new caffeoyl glycoside from Forsythia viridissima. Chemical and Pharmaceutical Bulletin, 32, 1209–1213.
9.
IshiiT, YanagisawaM. (1998) Synthesis, separation and NMR spectral analysis of methyl apiofuranosides. Carbohydrate Research, 313, 189–192
10.
KasaiR, OgawaK, OhtaniK, DingJK, ChenPQ, FeiCJ, TanakaO. (1991) Phenolic glycosides from Nuo-Mi-Xang-Cao, a Chinese Acanthaceous herb. Chemical and Pharmaceutical Bulletin, 39, 927–929.
11.
SaracogluI, InoueM, CalisI, OgiharaY. (1995) Studies on constituents with cytotoxic and cytostatic activity of two Turkish medicinal plants Phlomis armeniaca and Scutellaria salviifolia. Biological and Pharmaceutical Bulletin, 18, 1396–1400.
12.
NagaoT, AbeF, OkabeH. (2001) Antiproliferative constituents in the plants 7. Leaves of Clerodendron bungei and leaves and bark of C. trichotomum. Biological and Pharmaceutical Bulletin, 24, 1338–1341.
13.
AbeF, NagaoT, OkabeH. (2002) Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. Biological and Pharmaceutical Bulletin, 25, 920–922.
14.
LeeKW, KimHJ, LeeYS, ParkHJ, ChoiJW, HaJ, LeeKT. (2007) Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte. Carcinogenesis, 28, 1928–1936.
15.
LafkaTI, SinanoglouV, LazosES. (2007) On the extraction and antioxidant activity of phenolic compounds from winery wastes. Food Chemistry, 104, 1206–1214.
16.
Es-SafiNE, KollmannA, KhlifiS, DucrotPH. (2007) Antioxidative effect of compounds isolated from Globularia alypum L. structure-activity relationship. LWT, 40, 1246–1252.
17.
MosmannT. (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicty assays. Journal of Immunological Methods, 65, 55–63.
