Two new spirostane glycosides, chamaedrosides C (1) and C1 (2), two new furostane glycosides, chamaedrosides E (4) and E1 (5), and two new furospirostane glycosides, chamaedrosides C2 (3) and E2 (6), have been isolated from Veronica chamaedrys L. plants. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including 1D- and 2D-NMR experiments, as well as MS analysis. The given compounds have been found for the first time.
LahloubMF. (1983) Isolierung, charakterisierung und strukturaufklarung von glykosiden einiger Veronica-Arten (Scrophulariaceae). Thesis. ETH Nr. 7340, Zurich;
2.
SocolovPD. (1990) Tvekovie rasteniea i ih himiceskii sostav, ispolizovanie. In Rastitelinie resursi SSSR.Nauka, Leningrad, 173–182.
3.
TomassiniL, BrkicD, SerafiniM., (1995) Constituents of Veronica hederifolia and Veronica polita. Fitoterapia, 66, 382;
4.
SuB., ZhuQ, JiaZ., (1999) Aquaticol, a novel bis-sesquiterpene from Veronica anagallis-aquatica. Tetrahedron Letters, 40, 357–358;
5.
GrahamJG, QuinnML, FabricantDS, FarnsworthNR. (2000) Plants used against cancer – an extension of the work of Jonathan Hartwell. Journal of Ethnopharmacology, 73, 347–377.
TaskovaR, HandjievaN, PeevD, PopovS. (1998) Iridoid glucosides from three Veronica species. Phytochemistry, 49, 1323–1327;
8.
TaskovaR, HandjievaN, EvstatievaL, PopovS. (1999) Iridoid glucosides from Plantago cornuti, Plantago major and Veronica cymbalaria. Phytochemistry, 52, 1443–1445;
9.
OzipekM, SaracogluI, KojimaK, OgiharaY, CalisI. (1999) Fuhsioside, a new phenylethanoid glucoside from Veronica fuhsii. Chemical & Pharmaceutical Bulletin, 47, 561–562;
SaracogluI, HarputU, InoueM, OgiharaY. (2002) New phenylethanoid glycosides from Veronica pectinata var. glandulosa and their free radical scavenging activities. Chemical & Pharmaceutical Bulletin, 50, 665–668;
12.
HarputS, SaracogluI, YnoueM, OgiharaY. (2002) Phenylethanoid and iridoid glycosides from Veronica persica. Chemical & Pharmaceutical Bulletin, 50, 869–871.
13.
ChariVM, Grayer-BarkmeijerRJ, HarborneJB, OsterdahlBG. (1981) An acylated allose-containing 8-hydroxyflavone glycoside from Veronica filiformis. Phytochemistry, 20, 1977–1979.
14.
MarchenkoA, KintiaP, MashcencoN, BasarelloC, PiacenteS, PizzaC., (2008) Phenylethanoid and iridoid glycosides from Veronica chamaedrys L. Chemistry Journal of Moldova, 3, 101–104;
15.
AgrawalPK, JainDC, GuptaRK, ThakurRS. (1985) Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry, 24, 2479–2496.
16.
KostovaI, DincevD. (2005) Saponins in Tribulus terrestris – chemistry and bioactivity. Phytochemistry Review, 4, 111–113;
17.
AgrawalPK (2004) Dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins. Magnetic Resonance in Chemistry, 42, 990–993;
18.
KiyosawaS, HutohM, KomoriT, NoharaT, HosokawaI, KawasakiT. (1968) Detection of prototype compounds of diosgenin and other spirostanol-glycosides. Chemical & Pharmaceutical Bulletin, 16, 1162–1163.