Twelve compounds were isolated from Winged Sumac (Rhus copallinum) fruit and their structures were elucidated on the basis of NMR and mass spectral data. The isolates included a new galloyl derivative, (R)-galloyl malic acid dimethyl ester (1), and eleven known compounds, gallic acid (2), methyl gallate (3), glucogallin (4), methyl m-digallate (5), methyl p-digallate (6), quercetin (7), myricetin (8), rhamnazin (9), kaempferol (10), betulinic acid (11), and oleanolic acid (12). All of the compounds were evaluated for antiproliferative effects against human colon tumorigenic (HCT-116, Caco-2) and non-tumorigenic (CCD18-Co) cell lines.
YoshiharaT, SakamuraS. (1977) Benzoic acid derivatives conjugated with dicarboxylic acids from alfalfa (Medicago sativa). Agricultural Biological Chemistry, 41, 2427–2429.
6.
CaiB, WangB, LiangH, ZhaoY. (2009) Chemical constituents from roots of Distylium myricoides. Zhongguo Zhong Yao Za Zhi, 34, 2331–2333.
7.
MaX, WuL, ItoY, TianW. (2005) Application of preparative high-speed counter-current chromatography for separation of methyl gallate from Acer truncatum Bunge. Journal of Chromatography A, 1076, 212–215;
8.
LatteKP, KolodziejH. (2000) Pelargoniiins, new ellagitannins from Pelargonium reniforme. Phytochemistry, 54, 701–708;
9.
LinW, DengZ, LeiH, FuH, LiJ. (2002) Polyphenolic compounds from the leaves of Koelreuteria paniculata Laxm. Journal of Asian Natural Products Research, 4, 287–295;
10.
LiL, HenryGE, SeeramNP. (2009) Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seeds. Journal of Agricultural and Food Chemistry, 57, 7282–7287.
11.
LeeTH, ChiouJL, LeeCK, KuoYH. (2005) Separation and determination of chemical constituents in the roots of Rhus javanica L. var. roxburghiana. Journal of the Chinese Chemical Society, 52, 833–841;
12.
González-SarríasA, GromekS, NiesenD, SeeramNP, HenryGE. (2011) Resveratrol oligomers isolated from Carex species inhibit proliferation of human colon tumorigenic cells inhibited by cell cycle arrest. Journal of Agricultural and Food Chemistry, 59, 8632–8638;
13.
ZhaoC, GiustiMM, MalikM, MoyerMP, MagnusonBA. (2004) Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. Journal of Agricultural and Food Chemistry, 52, 6122–6128;
14.
NorattoGD, BertoldiMC, KrenekK, TalcottST, StringhetaPC, Mertens-TalcottSU. (2010) Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties. Journal of Agricultural and Food Chemistry, 58, 4104–4112.
