The essential oil from aerial parts of Seseli globiferum Vis. obtained by hydrodistillation with Clevenger-type apparatus was analyzed by GC-MS. Twenty-eight compounds were identified, representing 99.4% of the total oil. The main components of the oil were sabinene (38.0%), α-pinene (21.2%) and β-phellandrene (13.5%). The microbial growth inhibitory properties of the isolated essential oil were determined using the broth microdilution method against seven bacterial species: Salmonella typhimurium (ATCC 13311), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterobacter cloacae (clinical isolates), Bacillus cereus (clinical isolates), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Micrococcus flavus (ATCC 10240) and three fungal species: Aspergillus niger (ATCC 6275), Aspergillus versicolor (ATCC 11730), Trichoderma viride (IAM 5061) and Penicillium funiculosum (ATCC 36839). The essential oil showed activity against bacteria P. aeruginosa, followed by M. flavus, L. monocytigenes and E. coli, and all investigated fungal species.
BallP.W. (1978) Seseli L. In TutinT., HeywoodV., BurgesN. A., MooreD. M., ValentineD. H., WaltersS. M., Flora Europaea vol. 2 (pp. 334–338). Cambrigde: Cambridge University Press.
2.
Dioscorides. (2002) De Materia Medica.Athens: Militos Press.
3.
XieL., TakeuchiY., CosentinoL.M., LeeK-H. (1999) Anti-AIDS Agents. 37.1 Synthesis and Structure–Activity Relationships of (3′R,4′R)-(+)-cis-Khellactone Derivatives as Novel Potent Anti-HIV Agents. Journal of Medicinal Chemistry, 42, 2662–2672.
4.
KupeliE., TosunA., YesiladaE. (2006) Anti-inflammatory and antinociceptive activities of Seseli L. species (Apiaceae) growing in Turkey. Journal of Ethnopharmacology, 104, 310–314.
5.
KayaA., DemirciB., BaserK.H.C. (2003) The essential oil of Seseli tortuosum L. growing in Turkey. Flavour and Fragrance Journal, 18, 159–161.
6.
JamwalK., SethiO., ChopraI. (1963) Pharmacodynamical effects of a volatile fraction isolated from Seseli sibiricum Benth. Archive of International Pharmacodynamical Therapy, 143, 41–51.
7.
DixitV., ChaturvediR.V., TripathiS.C. (1992) Evaluation of some essential ils against pulse bettle (Callosobrucus chinensis). National Academy Science Letters, 15, 255–257.
8.
VučkovićI., TrajkovićV., MacuraS., TeševićV., JanaćkovićP. (2001) A Novel Cytotoxic Lignan from Seseli annuum L. Phytotherapy Research, 21, 790–792.
9.
MilosavljevićS., TeševićV., VučkovićI., JadraninM., VajsV., SokovićM., JanackovićP., JovanovićA. (2007) Composition and Antifungal Activity of the Essential Oil of Seseli annuum wild-growing in Serbia. Fitoterapia, 78, 319–322.
10.
StojkovićD., GlamočlijaJ., SokovićM., GrubišićD., PetrovićS., KukićJ., RistićM. (2008) Chemical composition, antimicrobial and antiradical properties of the essential oils of Seseli globiferum fruits. Natural Product Communications, 3, 1935–1938.
11.
DoganF., DumanH., TosunA., KürkçüogluM., BaserK.H.C. (2006) Essential oil composition of the fruits of Seseli resinosum Freyn et Sint. and Seseli tortuosum L. growing in Turkey. Journal of Essential Oil Research, 18, 57–59.
12.
Šavikin-FodulovićK.P., ZdunićG.M., TasićS.R. (2006) Essential oil of Seseli rigidum Waldst. et Kit. var. rigidum. Journal of Essential Oil Research, 18, 156–157.
TkachevA.V., KorolyukE.A., KönigW., KuleshovaY.V., LetchamoW. (2006) Chemical screening of volatile oil-bearing flora of Siberia VIII.: Variations in chemical composition of the essential oil of wild growing Seseli buchtormense (Fisch. ex Sprengel) W. Koch from different altitudes of Altai region. Journal of Essential Oil Research, 18, 100–103.
15.
BaserK.H.C., ÖzekT., NuriddinovKhR, NigmatullaevA.M., KhadzimatovKKh, AripovKhN. (1997) Essential oils of Mediasia macrophylla (Regel et Schmahl.) Pimen. and Foeniculum vulgare Mill., from Uzbekistan. Journal of Essential Oil Research, 9, 249–250.
WozniakK.S., LosR., GlowniakK., MalmA. (2010) Comparison of hydrodistillation and headspace solid-phase microextraction techniques for antibacterial volatile compounds from the fruits of Seseli libanotis. Natural Product Communications, 5, 1427–1430.
18.
KapetanosC., KariotiA., BojovicS., MarinP.D., VeljicM., SkaltsaH. (2008) Chemical and principal-component analyses of the essential oils of Apioideae Taxa (Apiaceae) from Central Balkan. Chemistry and Biodiversity, 5, 101–119.
19.
ShunyingZ., YangY., HuaidongY., YueY., GuolinZ. (2005) Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum. Journal of Ethnopharmacology, 96, 151–158.
20.
DukeJ.A. (1992) Handbook of phytochemical constituents of GRAS herbs and other economic plants.Boca Raton, FL, USA: CRC Press.
21.
Council of Europe. (2007) European Pharmacopoeia, 6th edition.Strasburg: European Directorate for the Quality of Medicines.
22.
NCCLS (2001) National Committee for Clinical Laboratory Standards: Performance standards for antimicrobial susceptibility testing: 11th informational supplement. Document M100-S11. Wayne, PA, USA.
