The essential oil of Matricaria pubescens (Asteraceae) collected at Ghardaia (Algerian Septentrional Sahara) was studied by GC and GC-MS. Isochrysanthemic acid ethyl ester (26.5%), spathulenol (19.4%), α-cadinol (12.9%) and geranylisovalerate (8.2%), were identified as the major components of the essential oil, which was investigated for its analgesic effect.
OzendaP. (1958) Flore du Sahara Septentrional et Central. C.N.R.S., Paris, France;
2.
BellakhdarJ, BaayaouiA, MarechalJ. (1987) Herboristes et médecine traditionnelle à Tissnit, oasis présaharien du sud-Marocain. Al Biruniya, Revue Marocaine de Pharmacie, 2930-50;
3.
BellakhdarJ. (1997) Pharmacopée marocaine, Ibiss press, France.
Lis-BalchinM, DeansSG, EagleshamE. (1998) Relationship between bioactivity and chemical composition of commercial essential oils. Flavour & Fragrance Journal, 13, 98-104.
6.
KosterR, AndersonM, De BeerJ. (1959) Acetic acid for analgesic screening. Federation proceedings, 18, 412–417.
7.
Daroui-MokaddemH, KaboucheA, BouachaM, SoumatiB, El-AzzounyA, BruneauC, KaboucheZ. (2010) GC/MS analysis and antimicrobial activity of the essential oil of fresh leaves of Eucalytus globulus, and leaves and stems of Smyrnium olusatrum from Constantine (Algeria). Natural Product Communications, 5, 1669-1672.
8.
AdamsRP. (2007) Identification of Essential Oil Components by Gas Chromatography / Mass Spectrometry, 4th Ed. Allured Publishing Co. Carol Stream, Illinois;
9.
MclaffertyFW, StaufferDB. (1991) The Important Peak Index of the Registry of Mass Spectral Data. John Wiley & Son, New York;
10.
SwigarAA, SilversteinRM. (1981) Monoterpenes-Infrared, Mass, Proton-NMR, Carbon-NMR Spectra and Kovats Indices. Aldrich Chemical Company Inc., Madison.
11.
CorrelT, JensenKM, SplawinskiJ. (1979) Interaction of salicylates and other non-steroidal anti-inflammatory agents in rats as shown by gastro-ulcerogenic and anti-inflammatory activities, and plasma concentrations. Acta Pharmacology and Toxicology, 45225-231;
12.
LeeSJ, BackHJ, LeeCH, KimHP. (1994) Anti-inflammatory activity of isoflavonoids from Pueraria radisc and biochanin- A derivatives. Archives of Pharmaceutical Research, 17, 31-35.
