(-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 μM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces Cerevisiae, Aspergilus Fumigatus, Alternaria Longipes, Piricularia Oryzae, Verticillium Albo-Atrum, Fusarium Culmorum, and F. nivale with IC50 values less than 20 μg/mL.
ProkshP, EdradaRA, EbelR. (2002)Drugs from the sea-current status and microbiological implications. Applied Microbiology and Biotechnology, 59125-134.
2.
BugniTS, IrelandCM. (2004)Marine-derived fungi: a chemically and biologically diverse group of microorganisms. Natural Product Reports, 21143-163.
3.
KanataniH, ShiraiH, NakanishiK, KurokawaT. (1969) Isolation and identification on meiosis inducing substance in starfish Asterias amurensis. Nature, 221, 273–274.
4.
MorinagaC, IzumiK, SawadaH, SawadaM.T. (2000)Activation of maturation promoting factor and 26S proteasome assembly accelerated by a high concentration of 1-methyladenine in starfish oocytes. Bioscience Biotechnology Biochemistry, 64268-274.
5.
KishimotoT, KanataniH. (1976)Cytoplasmic factor responsible for germinal vesicle breakdown and meiotic maturation in starfish oocyte. Nature, 260, 321–322.
6.
DunphyWG, BrizuelaL, BeachD, NewportJ. (1988)The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis.Cell, 54, 423–431.
7.
GautierJ, MinshullJ, LohkaM, GlotzerM, HuntT, MallerJ. (1990)Cyclin is a component of maturation-promoting factor from Xenopus.Cell, 60, 487–494.
8.
GautierJ, NorburyC, LohkaM, NurseP, MallerJ. (1988)Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell, 54, 433–439.
9.
TorayaT, MaokaT, TsujiH, KobayashiM. (1995) Purification and structural determination of an inhibitor of starfish oocyte maturation from a Bacillus species. Applied and Environmental Microbiology, 611799-1804.
10.
LiuHW, NamikoshiM, AkanoK, KobayashiH, NagaiN, YaoXS. (2005) Seven new meroditerpenoids, from the marine sponge Strongylophora strongylata, that inhibited the maturation of starfish oocytes. Journal of Asian Natural Products Research, 7661-670.
11.
LiuHW, NamikoshiM, MeguroS, NagaiH, KobayashiH, YaoXS. (2004) Isolation and characterization of polybrominated diphenyl ethers as inhibitors of tubulin polymerization from Palau sponge Phyllospongia dendyi. Journal of Natural Products, 67472-474.
12.
LiuHW, WangGH, NamikoshiM, KobayashiH, YaoXS, CaiGP. (2006) Sesquiterpene quinones from marine sponge Hippospongia sp. that inhibit maturation of starfish oocytes and induce cell cycle arrest with Hepg2 cells. Pharmaceutical Biology, 44522-527.
13.
DeanFM, StauntonJ, WaalleyWB. (1959)The chemistry of fungi. Part XXXVI. A revised structure for sclerotiorin. Journal of the Chemical Society, 3004-3009.
14.
YoshidaE, FujimotoH, BabaM, YamazakiM. (1995) Four new chlorinated azaphilones, Helicusins A-D, closely related to 7-epi-sclerotiorin, from an ascomycetous fungus, Talaromyces helicus. Chemical & Pharmaceutical Bulletin, 431307-1310.
15.
UdagawaS. (1963) (-)-Sclerotiorin, a major metabolite of Penicillium hirayamae. Chemical & Pharmaceutical Bulletin, 11366-367.
16.
PairetL, WrigleySK, ChetlandI, ReynoldsEE, HayesMA, HollowayJ, AinsworthAM, KatzerW, ChengXM, HupeDJ, CharltonP, DohertyAM. (1995) Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity. Journal of Antibiotics, 48913-923.
17.
ChidanandaCL, RaoJM, SatturAP. (2006)Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase. Biotechnology Letter, 28, 1633–1636.
18.
FujimotoH, MatsudoT, YamaguchiA, YamazakiM. (1990)Two new fungal azaphilones from Talaromyces luteus, with monoamine oxidase inhibitory effect. Heterocycles, 30, 607–616.
19.
AraiN, ShiomiK, TomodaH, TabataN, YangDJ, MasumaR, KawakuboT, OmuraS. (1995)Isochromophilones III–VI, inhibitors of acyl–CoA: cholesterol acyltransferase produced by Penicillium multicolor FO-3216. Journal of Antibiotics, 48, 696–702.
