A new isoflavone, 5-O-methyl-2′-methoxy-3′-methylalpinumisoflavone (1), together with four known compounds 6-methoxy-5,7,4′-trihydroxyisoflavone (2), 6-methoxy-7,4′-dihydroxyisoflavone (3), (+)-marmesin (4), and 4-methylbenzoic acid carboxymethyl ester (5), were isolated from the mangrove endophytic fungus, Fusarium sp. (ZZF41). Their structures were determined by analysis of spectroscopic data. Compound 1 inhibited HEp-2 and HepG2 cells with IC50 values of 4 and 11 μmol/mL, respectively.
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