Incubation of α-cedrol and caryophyllene oxide with Neurospora crassa afforded 12β-hydroxy cedrol, 10α-hydroxy cedrol, and 3β-hydroxy cedrol, and 12β-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.
FragaBM, GuillermoR, HansonJR, TrunehA. (1996) Biotransformation of cedrol and related compounds by Mucor plumbeus. Phytochemistry, 42, 1583–1586;
2.
YangD, MichelL, ChaumontJP, ClercJM. (1999) Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis. Mycopathologia, 148, 79–82;
HansonJR, NasirH. (1993) Biotransformation of the sesquiterpenoid cedrol by Cephalosporium aphidicola. Phytochemistry, 33, 835–839;
5.
MiyazawaM, NankaiH, KamcokaH. (1995) Biotransformation of (+)-cedrol by the plant pathogenic fungus, Glomerella cingulata. Phytochemistry, 40, 69–72;
6.
AleuJ, HansonJR, GalanRH, ColladoIG. (2001) Biotransformation of the fungistatic sesquiterpenoids patchoulol, ginsenol, cedrol and globulol by Botrytis cinerea. Journal of Molecular Catalysis B-Enzymatic, 11, 329–334;
7.
CollinsDO, ReesePB. (2001) Biotransformation of cedrol by Curvularia lunata ATCC 12017. Phytochemistry, 56, 417–421;
8.
MiyazawaM, ItsuzakiY, IshikawaK, IshisakaK. (2003) Stereospecific hydroxylation of (+)-cedrol by using human skin microbial flora Staphylococcus epidermidis. Natural Product Research, 17, 313–317.
9.
ChoudharyMI, SiddiquiZA, KhanS, Saifullah, MusharrafSG, Atta-Ur-Rahman. (2006) Biotransformation of (-)-caryophyllene oxide by cell suspension culture of Catharanthus roseus. Zeitschrift für Naturforschung B, 61, 197–200;
10.
OriharaY, SaikiK, FuruyaT. (1994) Studies on plant-tissue culture. 90. Biotransformation of caryophyllene oxide by cultured-cells of Eucalyptus perriniana. Phytochemistry, 35, 635–639;
11.
AsakawaY, IshidaT, ToyotaM, TakemotoT. (1986) Terpenoid biotransformation in mammals. 4. Biotransformation of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid in rabbits. Xenobiotica, 16, 753–767.
BibbinsM, SheffieldPL, GaineyLDS, MizoteT, ConnertonIF. (1998) Promoter analysis of the acetate-inducible isocitrate lyase gene (acu–3) from Neurospora crassa. Biochimica et Biophysica Acta, 1442, 320–325;
14.
PhadtareSu, RawatUB, RaoMB. (1997) Purification and characterization of xylitol dehydrogenase from Neurospora crassa. FEMS Microbiol Letters, 146, 79–83.
15.
CharneyW, HerzogHL. (1967) Microbial Transformation of Steroids, a Handbook.Academic Press, New York, pp. 269–273;
16.
MaugrasMM, SavignyP, LematreJ. (1973) Microbiological transformation of estrogens. 11β-hydroxylation of estradiol by Neurospora crassa. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D, 276, 3221–3223;
FaramarziMA, HajarolasvadiNH, YazdiMT, AminiM, AghelnejadM. (2007) Microbiological hydroxylation of androst-1,4-dien-3,17-dione by N. crassa. Biocatalysis and Biotransformation, 25, 72–78.
19.
KiranI, AkarT, GorguluA, KazazC. (2005) Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa. Biotechnology Letters, 27, 1007–1010;
20.
KiranI, YildirimHN, HansonJR, HitchcockPB. (2004) The antifungal activity and biotransformation of diisophorone by the fungus Aspergillus niger. Journal of Chemical Technology and Biotechnology, 79, 1366–1370.
21.
MaatooqG, El-SharkawyS, AfifiMS, RosazzaJPN. (1993) Microbial biotransformation of cedrol. Journal of Natural Products, 56, 1039–1050;
22.
DuranR, CorralesE, GalanRH, ColladoIG. (1999) Biotransformation of caryophyllene oxide by Botrytis cinerea. Journal of Natural Products, 62, 41–44.
23.
İşcanG, KirimerN, KürkcüoğrluM, BaşerKHC, DemirciF. (2002) Antimicrobial screening: Mentha piperita essential oil. Journal of Agriculture and Food Chemistry, 50, 3943–3946;
24.
KumarasamyY, FergussonME, NaharL, SarkerSD. (2002) Bioactivity of moschamindole from Centaurea moschata. Pharmaceutical Biology, 40, 307–310.