Staphylea preparations are used in TCM and have been used by native Americans for a number of indications, such as rheumatism. Based on this knowledge, the anti-inflammatory activity of light petroleum extracts of leaves of Staphylea colchica Stev., S. elegans Zab., S. holocarpa Hemsl. and S. pinnata L. has been determined using in vitro assays for inhibition of cyclooxygenase (COX-1 and COX-2) and leukotriene B4 (LTB4) formation by lipoxygenase (5-LOX). All extracts inhibited COX-1 and COX-2, with S. holocarpa and S. elegans performing best. Inhibition of LTB4 formation was less pronounced. As unsaturated fatty acids are known to inhibit arachidonic acid metabolism in vitro, the fatty acid content was determined of the active extracts and set in correlation with their activity. Unsaturated fatty acids were found to contribute to the observed COX-2 and LTB4 formation inhibitory activity to a different extent.
YuQ, OtsukaH, HirataE, ShinzatoT, TakedaY. (2002) Turpinionosides A - E megastigmane glucosides from leaves of Turpinia ternata Nakai. Chemical & Pharmaceutical Bulletin (Tokyo), 50, 640–644.
9.
MašterováI, WoldemichaelGM, TóthJ, UbikK. (2002) Lipophilic constituents of twigs of Staphylea holocarpa. Herba Polonica, 48, 94–97.
10.
LacikováL', MašterováI, GrančaiD. (2007) Constituents of the genus Staphylea L. Acta Facultatis Pharmaceuticae Universitatis Comenianae, 54, 104–108.
11.
GroveMD, WeislederD, DaxenbichlerME. (1973) Pinnatanine and oxypinnatanine. Novel amino acid amides from Staphylea pinnata L. Tetrahedron, 29, 2715–2719.
12.
MoritaN, ShimizuN, UchidaS. (1968) Studies on medical resources. XXXI. Component of the leaves of Staphylea bumalda. Yakugaku Zasshi, 88, 1311–1312.
13.
LobitzGO, HeilmannJ, ZschockeS, Tamayo-CastilloG, BauerR, MerfortI. (1998) Bornyl cinnamate derivatives with anti-inflammatory activity from Verbesina turbacensis. Pharmaceutical and Pharmacological Letters, 8, 115–118.
14.
Paubert-BraquetM, Menica HuertaJM, CousseH, BraquetP. (1997) Effect of the lipidic lipidosterolic extract of Serenoa repens (Permixon®) on the ionophore A23187-stimulated stimulated production of leukotriene B4 (LTB4) from human polymorphonuclear neutrophils. Prostaglandins, Leukotrienes and Essential Fatty Acids, 57, 299–304.
15.
JantováS, NagyM, RužekováL, GrančaiD. (2000) Antibacterial activity of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae. PhytotherapyResearch, 14, 601–603.
16.
JantováS, NagyM, RužekováL, GrančaiD. (2001) Cytotoxic effects of plant extracts from the families Fabaceae, Oleaceae, Philadelphaceae, Rosaceae and Staphyleaceae. Phytotherapy Research, 15, 22–25.
17.
LacikováL', MuselíkJ, MašterováI, GrančaiD. (2007) Antioxidant activity and phenolic compounds in different extracts of four Staphylea L. species. Molecules, 12, 98–102.
18.
LacikováL', UrbančíkováB, BukovskýM, MašterováI, GrančaiD. (2008) Immunomodulating activity of leaf decoctions from four Staphylea L. species. Herba Polonica, 53, 57–62.
19.
LiuHJ, ZschockeS, ReinigerE, BauerR. (1998) Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. Planta Medica, 64, 525–529.
20.
ReinigerEA, BauerR. (2006) Prostaglandin-H-synthase (PGHS-1) and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzymes by polyansaturated fatty acids from Platycodi radix. Phytomedicine, 13, 164–169.
21.
BodensieckA. PhD Thesis, Institute of Pharmaceutical Sciences, University of Graz, Graz: Austria, (2008) in preparation.
22.
FiebichBL, GrozdevaM, HessS, HullM, DaneschU, BodensieckA, BauerR. (2005) Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells. Planta Medica, 71, 12–19.
23.
AdamsM, KunertO, HaslingerE, BauerR. (2004) Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Medica, 70, 904–908.
24.
KnödlerM, KonradJ, WenzigEM, BauerR, LacornM, BeifussU, CarleR, SchieberA. (2008) Antiinflammatory 5-(11Z-heptadecenyl)- and 5-(8Z,11Z-heptadecadienyl)-resorcinol from mango (Mangifera indica L.) peels. Phytochemistry, 69, 988–993.
