Chemical modifications of parthenin, a naturally occurring bioactive sesquiterpenoid, were carried out in regio- and stereoselective manners using various inexpensive reagents to form different natural and unnatural analogues. Reactions including dehydration, reduction, alkylation, addition and hydroxylation have been studied. In some of the analogues, the α-methylene-γ-lactone moiety, which plays a vital role for bioactivity of parthenin, remained intact.
Part 27 in the series, “Synthetic studies on natural products”.
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