The Kalanchoe genus (syn. Bryophyllum), family Crassulaceae, comprises 125 species, most of them native to Madagascar. The great importance of several of these species for the traditional medicine in several regions of the World, esspecially India, Africa, China and Brazil, stimulated research programs into these plants from both a pharmacological and chemical point of view. The present review focuses on the main results obtained during the last decade on the secondary metabolites isolated from these species – endowed or not with a specific biological profile – with emphasis on flavonoids. The distribution of these molecules in the genus will be summarized and special attention will be given to K. brasiliensis and K. pinnata, two species well-known for healing inflammatory and infectious processes. Ornamental Kalanchoe species are also discussed as a potential source of bioactive compounds. This review covers the period 1970–2008.
Allorge-BoiteauL. (1996) Madagascar centre de speciation et d'origine du genre Kalanchoe (Crassulaceae). In Biogéographie de Madagascar.LourençoWR (Ed). Éditions de l'ORSTOM, Paris, 137–145.
2.
LucasV, MachadoO. (1946) Contribuição ao estudo das plantas medicinais brasileiras-Saião. Revista da Flora Medicinal, 77, 1–39.
3.
LipetzJ. (1967) Wound healing in Kalanchoe. Annals of the New York Academy of Sciences, 144, 320–325.
CostaSS, JossangA, BodoB, SouzaMLM, MoraesVLG. (1994) Patuletin acetylrhamnosides from Kalanchoe brasiliensis as inhibitors of human lymphocyte proliferative activity. Journal of Natural Products, 57, 1503–1510.
6.
Da SilvaSA, CostaSS, MendonçaSC, SilvaEM, MoraesVL, Rossi-BergmannB. (1995) Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis. Acta Tropica, 60, 201–210.
7.
Rossi-BergmannB, CostaSS, MoraesVLG. (1997) Brazilian medicinal plants: a rich source of immunomodulatory substances. Ciência e Cultura, 49, 395–401.
8.
MourãoRH, SantosFO, FranzottiEM, MorenoMP, AntoniolliAR. (1999) Antiinflammatory activity and acute toxicity (LD50) of the juice of Kalanchoe brasiliensis Camb. leaves picked before and during blooming. Phytotherapy Research, 13, 352–354.
9.
Da SilvaSA, CostaSS, Rossi-BergmannB. (1999) The anti-leishmanial effect of Kalanchoe is mediated by nitric oxide intermediates. Parasitology, 118, 575–582.
10.
Umbuzeiro-ValentG, RoubicekDA, HaebischEM. (1999) Mutagenic and antimutagenic evaluation of the juice of the leaves of Bryophyllum calycinum (Kalanchoe pinnata), a plant with antihistamine activity. Environmental and Molecular Mutagenesis, 33, 325–327.
11.
AlmeidaAP, Da SilvaSA, SouzaML, LimaLM, Rossi-BergmannB, MoraesVLG, CostaSS. (2000) Isolation and chemical analysis of a fatty acid fraction of Kalanchoe pinnata with a potent lymphocyte suppressive activity. Planta Medica, 66, 134–137.
12.
SupratmanU, FujitaT, AkiyamaK, HayashiH, MurakamiA, SakaiH, KoshimizuK, OhigashiH. (2001) Anti-tumor promoting activity of bufadienolides from Kalanchoe pinnata and K. daigremontiana x tubiflora. Bioscience, Biotechnology, and Biochemistry, 65, 947–949.
13.
IbrahimT, CunhaJMT, MadiK, Da FonsecaLMB, CostaSS, KoatzVLG. (2002) Immunomodulatory and anti-inflammatory effects of Kalanchoe brasiliensis. International Immunopharmacology, 2, 875–883.
14.
Miranda-BeltránML, Puebla-PérezAM, Guzmán-SánchezA, Huacuja-RuizL. (2003) Male rat infertility induction/spermatozoa and epididymal plasma abnormalities after oral administration of Kalanchoe gastonis bonnieri natural juice. Phytotherapy Research, 17, 315–319.
15.
Torres-SantosEC, Da SilvaSA, CostaSS, SantosAP, AlmeidaAP, Rossi-BergmannB. (2003) Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous leishmaniasis. Phytotherapy Research, 17, 801–803.
16.
YadavNP, DixitVK. (2003) Hepatoprotective activity of leaves of Kalanchoe pinnata Pers. Journal of Ethnopharmacology, 86, 197–202.
17.
NguelefackTB, FotioAL, WatchoP, WansiSL, DimoT, KamanyiA. (2004) Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae). Phytotherapy Research, 18, 385–388.
18.
BoiteauP, Allorge-BoiteauL. (1995) Kalanchoe (Crassulacées) de Madagascar. Systématique, écophysiologie et phytochimie.Karthala, Paris.
19.
McKenzieRA, DunsterPJ. (1986) Hearts and flowers: Bryophyllum poisoning of cattle. Australian Veterinary Journal, 63, 222–227.
20.
WilliamsMC, SmithMC. (1984) Toxicity of Kalanchoe spp to chicks. American Journal of Veterinary Research, 45, 543–546.
21.
BrulfertJ, RavelomananaD, KlugeM. (1995) Ecophysiologie des Kalanchoe. Le métabolisme acide des Crassulacées (CAM), une voie photosynthétique adaptative. In Kalanchoe (Crassulacées) de Madagascar. Systématique, écophysiologie et phytochimie.Allorge-BoiteauL (Ed). Karthala, Paris, 207–218.
22.
WinterK, RichterA, EngelbrechtB, PousadaJ, VirgoA, PoppM. (1997) Effect of elevated CO2 on growth and crassulacean-acid-metabolism activity of Kalanchoe pinnata under tropical conditions. Planta, 201, 389–396.
23.
CheffingsCM, PantojaO, AshcroftFM, SmithJAC. (1997) Malate transport and vacuolar ion channels in CAM plants. Journal of Experimental Botany, 48, 623–631.
24.
LüttgeU. (2004) Ecophysiology of Crassulacean acid metabolism (CAM). Annals of Botany, 93, 629–652.
GaindKN, GuptaRL. (1973) Phenolic components from the leaves of Kalanchoe pinnata. Planta Medica, 23, 149–153.
27.
VeitchNC, GrayerREJ. (2008) Flavonoids and their glycosides, including anthocyanins. Natural Product Reports, 25, 555–611.
28.
MiddletonE, KandaswamiC, TheoharidesTC. (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews, 52, 673–751.
29.
SteynPS, Van HeerdenFR. (1998) Bufadienolides of plant and animal origin. Natural Products Reports, 15, 397–413.
30.
McKenzieRA, FrankeFP, DunsterPJ. (1987) The toxicity to cattle and bufadienolide content of six Bryophyllum species. Australian Veterinary Journal, 64, 298–301.
31.
CostaSS, JossangA, BodoB. (1995) Propriétés biologiques et phytochimie des Kalanchoe. In Kalanchoe (Crassulacées) de Madagascar. Systématique, écophysiologie et phytochimie.Allorge-BoiteauL (Ed). Karthala, Paris, 219–235.
32.
MoraesVLG, SantosLFM, CastroSB, LoureiroLH, LimaOA, LimaMLM, YienLMK, Rossi-BergmannB, CostaSS. (1994) Inhibition of lymphocyte activation by extracts and fractions of Kalanchoe, Alternanthera, Paullinia and Mikania species. Phytomedicine, 1, 199–204.
33.
LiuKCS, LinYS, RobertsMF, PhillipsonJD. (1989a) Flavonol glycosides with acetyl substitution from Kalanchoe gracilis. Phytochemistry, 28, 2813–2818.
34.
SouzaMLM. (1995) Estudo químico de flavonóides isolados de Kalanchoe brasiliensis Camb. com atividade sobre o sistema imunológico. MSc Thesis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
35.
TrevisanMTS, BezerraMZB, SantiagoGMP, FeitosaCM. (2006) Atividades larvicida e anticolinesterásica de plantas do gênero Kalanchoe. Química Nova, 29, 415–418.
36.
De CunhaAGM, MaiaAAB, NériEDR, NogueiraNAP, MatosFJA. (1995) Antimicrobial activity of medicinal plants. Revista Brasileira de Farmácia, 76, 5–6.
37.
De AlmeidaCCS, BogossianFB, DoiAPK, IsoyamaD, Ho SihG, ZanollaWR, NassisCZ. (1997) Study of antihistamine activity of Kalanchoe brasiliensis. Arquivos Brasileiros de Cardiologia, 20, 7–10.
38.
FonsecaFV, MeloMM, SilvaJ, PereiraGP, Dantas-BarrosAM. (2004) Extratos de Curcuma longa L. e Kalanchoe brasiliensis Camb. no tratamento local do envenenamento por Bothrops alternatus. Revista Brasileira de Farmacognosia, 14, 26–29.
39.
FerreiraACF, RosenthalD, CarvalhoDP. (2000) Thyroid peroxidase inhibition by Kalanchoe brasiliensis aqueous extract. Food and Chemical Toxicology, 38, 417–421.
40.
AlmeidaAP. (2000) Extratos de Kalanchoe pinnata (Crassulaceae), uma planta usada na medicina popular: estudo químico guiado pelo ensaio de proliferação de linfócitos. PhD Thesis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
41.
ReynaudJ, RaynaudJ. (1986) Les flavonoïdes de Doronicum grandiflorum. Biochemical Systematics and Ecology, 14, 191–193.
42.
StevensJF, HartH, ElemaET, BolckA. (1996) Flavonoid variation in eurasian Sedum and Sempervivum. Phytochemistry, 41, 503–512.
CroftSL, YardleyV. (2002) Chemotherapy of Leishmaniasis. Current Pharmaceutical Design, 8, 319–342.
45.
Torres-SantosEC, Da SilvaSAG, CostaSS, SantosAPPT, AlmeidaAP, Rossi-BergmannB. (2003) Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous Leishmaniasis. Phytotherapy Research, 17, 801–803.
MuzitanoMF, TinocoLW, GuetteC, KaiserCR, Rossi-BergmannB, CostaSS. (2006) Assessment of antileishmanial activity of new and unusual flavonoids from Kalanchoe pinnata. Phytochemistry, 67, 2071–2077.
48.
CruzEA, Da-SilvaSAG, MuzitanoMF, SilvaPMR, CostaSS, Rossi-BergmannB. (2008) Immunomodulatory pretreatment with Kalanchoe pinnata extract and its quercitrin flavonoid effectively protects mice against fatal anaphylactic shock. International Immunopharmacology, 8, 1616–1621.
PalS, ChaudhuriAKN. (1991) Studies on the antiulcer activity of a Bryophyllum pinnatum leaf extract in experimental animals. Journal of Ethnopharmacology, 33, 97–102.
54.
HemaD, TidjaniM, BasseneE, PoussetL, Giono-BarberH. (1986) Plantes médicinales africaines XXIV. Étude de l'action anti-inflammatoire de Bryophyllum pinnatum (Crassulacées). Plantes Médicinales et Phytothérapie, 3, 231–235.
55.
MuñozV, SauvainM, BourdyG, CallapaJ, RojasI, VargasL, TaeA, DeharoE. (2000) The search for natural bioactive compounds through a multidisciplinary approach in Bolivia. Part II. Antimalarial activity of some plants used by Mosetene Indians. Journal of Ethnopharmacology, 69, 139–155.
56.
PalS, SenT, ChaudhuriAKN. (1999) Neuropsychopharmacological profile of the methanolic fraction of Bryophyllum pinnatum leaf extract. Journal of Pharmacy and Pharmacology, 51, 313–318.
57.
YemitanOK, SalahdeenHM. (2005) Neurosedative and muscle relaxant activities of aqueous extract of Bryophyllum pinnatum. Fitoterapia, 76, 187–193.
58.
GwehenbergerB, RistL, HuchR, von MandachU. (2004) Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility. European Journal of Obstetrics & Gynecology and Reproductive Biology, 113, 164–171.
59.
PlanggerN, RistL, ZimmermannR, von MandachU. (2006) Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application. European Journal of Obstetrics & Gynecology and Reproductive Biology, 124, 168–172.
60.
JouSJ, ChenCH, GuhJH, LeeCN, LeeSS. (2004) Flavonol glycosides and cytotoxic triterpenoids from Alphitonia philippinensis. Journal of the Chinese Chemical Society, 51, 827–834.
61.
NielsenAH, OlsenCE, MollerBL. (2005) Flavonoids in flowers of 16 Kalanchoe blossfeldiana varieties. Phytochemistry, 66, 2829–2835.
62.
YamagishiT, YanXZ, WuRY, McphailDR, McphailAT, LeeKH. (1988) Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum. Chemical and Pharmaceutical Bulletin, 36, 1615–1617.
63.
YamagishiT, HarunaM, YanX-Z, ChangJ-J, LeeK-H. (1989) Antitumor Agents, 110. 1,2 Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum. Journal of Natural Products, 52, 1071–1079.
64.
SupratmanU, FujitaT, AkiyamaK, HayashiH. (2000) New insecticidal bufadienolide, bryophyllin C, from Kalanchoe pinnata. Bioscience, Biotechnology, and Biochemistry, 64, 1310–1312.
65.
OsoskiAL, LohrP, ReiffM, BalickMJ, KronenbergF, Fugh-BermanA, O'ConnorB. (2002) Ethnobotanical literature survey of medicinal plants in the Dominican Republic used for women's health conditions. Journal of Ethnopharmacology, 79, 285–298.
66.
LiuKCS, YangSL, RobertsMF, PhillipsonJD. (1989b) Eupafolin rhamnosides from Kalanchoe gracilis. Journal of Natural Products, 52, 970–974.
67.
WuP-L, HsuY-L, WuT-S, BastowKF, LeeK-H. (2006) Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis. Organic Letters, 8, 5207–5210.
68.
KuoP-C, KuoT-H, SuC-R, LiouM-J, WuT-S. (2008) Cytotoxic principles and α-pyrone ring-opening derivatives of bufadienolides from Kalanchoe hybrida. Tetrahedron, 64, 3392–3396.
CastriciniSD. (2004) Estudo fitoquímico de Kalanchoe fedtschenkoi (Crassulaceae) e avaliação do efeito de suas frações flavonoídicas em células tumorais. MSc Thesis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
71.
CostaSS, JossangA, BodoB. (1996) 4″”-Acetylsagittatin A, a kaempferol triglycoside from Kalanchoe streptantha. Journal of Natural Products, 59, 327–329.
72.
RazanamahefaB, DemetzosC, SkaltsounisAL, AndriantisiferanaM, TillequinF. (1994) Structure and synthesis of a quercetin glucoxyloside from Kalanchoe prolifera Raym-Hamet. Heterocycles, 38, 357–373.
73.
OgumgbamilaFO, OnawunmiGO, AndeosunO. (1997) A new acylated flavan-3-ol from Bryophyllum pinnatum. Natural Products Letters, 10, 201–203.
74.
JoshiAR, EdingtonJM. (1990) The use of medicinal plants by two village communities in the central development region of Nepal. Economic Botany, 44, 71–83.
75.
DemetzosC, SkaltsounisAL, RazanamahefaB, TillequinF. (1994) Synthesis of quercetin-3-O-β-D-glucopyranosyl-(1→2)-β-D-xylopyranoside via orthoester methodology. Journal of Natural Products, 57, 1234–1238.
76.
AndersonLA, SchultzRA, JoubertJP, ProzeskyL, KellermanTS, ErasmusGL, ProcosJ. (1983) Krimpsiekte and acute cardiac glycoside poisoning in sheep caused by bufadienolides from the plant Kalanchoe lanceolata Forsk. Onderstepoort Journal of Veterinary Research, 50, 295–300.
77.
AndersonLAP, SteynPS, Van HeerdenFR. (1984) The characterization of two novel bufadienolides, lanceotoxin A and B from Kalanchoe lanceolata [Forssk] Pers. Journal of the Chemical Society, Perkin Transactions1, 1573–1575.
78.
NguelefackTB, NanaP, AtsamoAD, DimoT, WatchoP, DongmoAB, TapondjouLA, NjamenD, WansiSL, KamanyiA. (2006) Analgesic and anticonvulsant effects of extracts from the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). Journal of Ethnopharmacology, 106, 70–75.
79.
KamgangR, MboumiRY, FondjoAF, TagneMA, N'dilléGP, YonkeuJN. (2008) Antihyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae). Natural Medicine, 62, 34–40.
80.
VargasCS. (2008) Identificación de sustancias con actividad antiviral contra el Herpes simplex tipo 1 (HSV-1) y tipo 2 (HSV-2) presentes en las flores y las hojas de Kalanchoe blossfeldiana Poelln (Crassulaceae). BSc Thesis, Pontificia Universidad Javeriana, Bogota, Colômbia.
81.
RasonaivoP, GaleffiC, MultariG, NicolettiM, CapolongoL. (1993) Kalanchoside, a cytotoxic bufadienolidic glycoside from Kalanchoe tomentosa Baker. Gazzeta Chimica Italiana, 123, 539–541.
82.
WagnerH, FischerM, LotterH. (1985) Isolation and structure determination of daigremontianin, a novel bufadienolide from Kalanchoe daigremontiana. Planta Medica, 169–170.
83.
FoucheG, CraggGM, PillayG, KolesnikovaN, MaharajVJ, SenabeJ. (2008) In vitro anticancer screening of South African plants. Journal of Ethnopharmacology, 119, 455–461.
LiuY, MurakamiN, JiH, AbreuP, ZhangS. (2007) Antimalarial flavonol glycosides from Euphorbia hirta. Pharmaceutical Biology, 45, 278–281.
86.
RibeiroAB, BolzaniVD, YoshidaM, SantosLS, EberlinMN, SilvaDHS. (2005) A new neolignan and antioxidant phenols from Nectandra grandiflora. Journal of the Brazilian Chemical Society, 16, 526–530.
87.
MinBS, LeeSY, KimJH, LeeJK, KimTJ, KimDH, KimYH, JoungH, LeeHK, NakamuraN, MiyashiroH, HattoriM. (2003) Anti-complement activity of constituents from the stem-bark of Juglans mandshurica. Biological & Pharmaceutical Bulletin, 26, 1042–1044
88.
KotaniM, MatsumotoM, FujitaA, HigaS, WangW, SuemuraM, KishimotoT, TanakaT. (2000) Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. Journal of Allergy and Clinical Immunology, 106, 159–166.
89.
LiuX, CuiC, ZhaoM, WangJ, LuoW, YangB, JiangY. (2008) Identification of phenolics in the fruit of emblica (Phyllanthus emblica L.) and their antioxidant activities. Food Chemistry, 109, 909–915.
90.
CalzadaF, AlanisAD. (2007) Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum. Phytotherapy Research, 21, 78–80.
91.
WagnerC, FachinettoR, Dalla CorteCL, BritoVB, SeveroD, de Oliveira Costa DiasG, MorelAF, NogueiraCW, RochaJB. (2006) Quercitrin, a glycoside form of quercetin, prevents lipid peroxidation in vitro. Brain Research, 1107, 192–198.
92.
RotelliAE, GuardiaT, JuárezAO, De la RochaNE, PelzerLE. (2003) Comparative study of flavonoids in experimental models of inflammation. Pharmacological Research, 48, 601–606.
93.
BorrelliF, IzzoAA. (2000) The plant kingdom as a source of anti-ulcer remedies. Phytotherapy Research, 14, 581–591.
94.
CiminoF, AmbraR, CanaliR, SaijaA, VirgiliF. (2006) Effect of cyanidin-3-O-glucoside on UVB-induced response in human keratinocytes. Journal of Agriculture and Food Chemistry, 54, 4041–4047.
95.
SerrainoI, DugoL, MondelloL, MazzonE, DugoG, CaputiAP, CuzzocreoS. (2003) Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sciences, 73, 1097–1114.
96.
KoleckarV, BrojerovaE, RehakovaZ, KubikovaK, CervenkaF, KucaK, JunD, HronekM, OpletalovaV, OpletalL. (2008) In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug and Chemical Toxicology, 31, 27–35.
97.
KimSR, ParkMJ, LeeMK, SungSH, ParkEJ, KimJ, KimSY, OhTH, MarkelonisGJ, KimYC. (2002) Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. Free Radical Biology & Medicine, 32, 596–604.
98.
LiS, MaoW, CaoX, LiangS, DingZ, LiN. (1991) Inhibition of rat lens aldose reductase by quercetagetin and patuletin. Yan Ke Xue Bao, 7, 29–33.
99.
RobakJ, ShridiF, WolbísM, KrólikowskaM. (1988) Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation. Polish Journal of Pharmacology and Pharmacy, 40, 451–458.
100.
FaiziS, SiddiqiH, BanoS, NazA, Lubna MazharK, NasimS, RiazT, KamalS, AhmadA, KhanAS. (2008) Antibacterial and antifungal activities of different parts of Tagetes patula: preparation of patuletin derivatives. Pharmaceutical Biology, 46, 309–320.
101.
Maleki-DizajiN, FathiazadF, GarjaniA. (2007) Antinociceptive properties of extracts and two flavonoids isolated from leaves of Danae racemosa. Archives of Pharmacal Research, 30, 1536–1542.
102.
López-SánchezC, Martín-RomeroFJ, SunF, LuisL, Samhan-AriasAK, García-MartínezV, Gutiérrez-MerinoC. (2007) Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. Brain Research, 1182, 123–137.
103.
TuY-C, LianT-W, YenJ-H, ChenZ-T, WuM-J. (2007) Antiatherogenic effects of kaempferol and rhamnocitrin. Journal of Agricultural and Food Chemistry, 55, 9969–9976.
104.
BestwickCS, MilneL, DuthieSJ. (2007) Kaempferol induced inhibition of HL-60 cell growth results from a heterogeneous response, dominated by cell cycle alterations. Chemico-Biological Interactions, 170, 76–85.
105.
LeungHWC, LinCJ, HourMJ, YangWH, WangMY, LeeHZ. (2007) Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food and Chemical Toxicology, 45, 2005–2013.
106.
HyunSK, JungHA, ChungHY, ChoiJS. (2006) In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves. Archives of Pharmacal Research, 29, 1074–1079.
107.
MorikawaK, NonakaM, NaraharaM, ToriiI, KawaguchiK, YoshikawaT, KumazawaY, MorikawaS. (2003) Inhibitory effect of quercetin on carrageenan-induced inflammation in rats. Life Sciences, 74, 709–721.
108.
AbeF, NagaoT, OkabeH. (2002) Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. Biological & Pharmaceutical Bulletin, 25, 920–922.
109.
MiuraK, KikuzakiH, NakataniN. (2002) Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. Journal of Agricultural and Food Chemistry, 50, 1845–1851.
110.
SteffenY, GruberC, ScheweT, SiesH. (2008) Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Archives of Biochemistry and Biophysics, 469, 209–219.
111.
XuYC, LeungSW, YeungDK, HuLH, ChenGH, CheCM, ManRY. (2007) Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. Phytochemistry, 68, 1179–1188.
112.
PelzerLE, GuardiaT, JuarezAO, GuerreiroE. (1998) Acute and chronic anti-inflammatory effects of plant flavonoids. Il Farmaco, 53, 421–424.
113.
KimM-J, KimD-H, LeeKW, YoonD-Y, SurhY-J. (2007) Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. Annals of the New York Academy of Sciences, 1095, 483–495.
114.
LeeSH, BaeE-A, ParkE-K, ShinY-W, BaekN-I, HanE-J, ChungH-G, KimD-H. (2007) Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. International Immunopharmacology, 7, 1678–1684.
RivièreC, RichardT, VitracX, MerillonJ-M, VallsJ, MontiJ-P. (2008) New polyphenols active on beta-amyloid aggregation. Bioorganic & Medicinal Chemistry Letters, 18, 828–831.
117.
LeeSJ, ChoiJH, SonKH, ChangHW, KangSS, KimHP. (1995) Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids. Life Sciences, 57, 551–558.
118.
CherngJ-M, ChiangW, ChiangL-C. (2008) Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chemistry, 106, 944–950.
119.
MookerjeeBK, LeeTP, LippesHA, MiddletonEJr. (1986) Some effects of flavonoids on lymphocyte proliferative responses. Journal of Immunopharmacology, 8, 371–392.
