Some of the more potent, and interesting, natural products that have marked biocidal properties have one, or more, amide functional groups. On the other hand, there are countless amides that are non-toxic. Thus, there is a need to try to identify the structural features of biocidal amides that could indicate their potential toxicity. A review of the structures of some of these toxic amides, using the molecular modeling program STR3DI32, has established that these amide groups are non-delocalized.
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The STR3DI32.EXE molecular modeler may be obtained from Exorga, Inc., P. O. Box 56, Colonia, NJ 07067, or at http://www.Exorga.com.
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