Two new xanthone glycosides, 8-hydroxy-3-methyl-6-methoxyxanthone-1-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranose (1) and 8-hydroxy-3-methyl-6-methoxyxanthone-1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranose (2), together with two known anthraquinones, 1,8-dihydroxy-3-methylanthraquinone (3) and 1,3,8-trihydroxy-6-methylanthraquinone (4), were isolated from the bark of Ventilago leiocarpa Benth. The structures were determined by various NMR spectroscopic and MS analyses. Compounds 1–4 were tested for their inhibitory activities against T and B cell proliferation, and 2 exhibited moderate inhibitory activities against LPS-induced B cell proliferation and ConA-induced T cell proliferation, with IC50 values of 8.8 and 17.9 μM, respectively.
WangXW, XuSX. (1995) Study on the progress of chemical constituents in genus Ventilago. Journal of Shenyang Pharmaceutical University, 12, 64–68.
2.
WangXW, XuSX, WangZX, SunBY. (1996) Study of chemical constituents in Ventilago Leiocarpa Benth. Journal of Shenyang Pharmaceutical University, 13, 189–192;
3.
WangXW, XuSX, WangZX, ZhouCS, LiRH. (1997) A new compound in Ventilago Leiocarpa Benth.. Journal of Shenyang Pharmaceutical University, 14, 296–297;
4.
LinLC, ChouCJ, KuoYC. (2001) Cytotoxic principles from Ventilago leiocarpa. Journal of Natural Products, 64, 674–676.
5.
BiliaAR, YusufAW, BracaA, KeitaA, MorelliI. (2000) New prenylated anthraquinones and xanthones from Vismia guineensis. Journal of Natural Products, 63, 16–21.
6.
DonnellyDMX, SheridanMH. (1986) Anthraquinones from Trichoderma polysporum. Phytochemistry, 25, 2303–2304.
7.
ChanAWK, CrowWD. (1966) Chemical constituents of Eriococcus confusus Maskell. Australian Journal of Chemistry, 19, 1701–1708.
8.
ZhangYN, ZhongXG, ZhengZP, HuXD,. ZuolP, HuLH. (2007) Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hems!.) Merr.. Bioorganic & Medicinal Chemistry, 15, 988–996.
