A new lupane triterpenoid, 27-hydroxylup-20(29)-en-27-O-(3,4-dimethoxycinnamoyl)-28-oic acid methyl ester (1) was isolated from the seeds of Peganum harmala. The structure was determined from extensive 1D- and 2D- NMR spectroscopic data.
ChopraRN, NayarSL, ChopraIC. (1956) Glossary of Indian Medicinal Plants, p.187.
2.
FarzinD, MansouriN. (2006) Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test. European Neuropsychopharmacology, 16, 324–328.
3.
GlennonRA, DukatM, GrellaB, HongSS, CostantinoL, TeitlerM, SmithC, EganC, DavisK, MattsonMV. (2000) Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors. Drug and Alcohol Dependence, 60, 121–132.
4.
GiorgioCD, DelmasF, OllivierE, EliasR, BalansardG, DavidaPT. (2004) In vitro activity of the β-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Experimental Parasitology, 106, 67–74.
5.
GuanH, LiuX, XuA. (2005) Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal of Medicinal Chemistry, 40, 991–1001
6.
IshidaJ, WangH-W, OyamaM, CosentinoML, HuC-Q, LeeK-H. (2001) Anti-AIDS agents: Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives. Journal of Natural Products, 64, 958–960.
7.
MaZZ, HanoY, NomuraT, ChenJ. (2000) Three new triterpenoids from Peganum nigellastrum.Journal of Natural Products, 63, 390–392.
