In spite of several studies of Stachys species, the literature lacks any information about the constituents of S. yemenensis Hedge. We report here the isolation of a new sesquiterpenetriol, stachytriol (1), along with the known compounds β-sitosterol (2), ursolic acid (3), penduletin (4), and benghalensin B (5). The structure elucidation of all isolated compounds was performed by extensive 1D and 2D NMR spectroscopic investigation.
MabberleyDJ. (1990) The Plant Book.Cambridge University Press, Cambridge, New York, Port Chester, Melbourne, Sydney, p. 552.
2.
KobzarAY. (1986) Phytochemical study of Betonica officinalis. I. Isolation of biologically active substances from the aerial parts of the plant. Khimiya Prirodnykh Soedinenii, 2, 239–240. (Chemical Abstracts 105, 168943)
3.
KimS, KimD, EomD, ParkJ, LimJ, KimS, ShinH, KimS, ShinT. (2003) Anti-allergic effect of aqueous extract of Stachys riederi var. japonica Miq. in vivo and in vitro.Natural Product Sciences, 9, 44–48.
4.
ShinT. (2004) Stachys riederi inhibits mast cell-mediated acute and chronic allergic reactions. Immunopharmacology and Immunotoxicology, 26, 621–630.
5.
SonboliA, SalehiP, Nejad EbrahimiS. (2005) Essential oil composition and antibacterial activity of the leaves of Stachys schtschegleevii from Iran. Chemistry of Natural Compounds, 41, 171–174.
6.
SkaltsaHD, DemetzosC, LazariD, SokovicM. (2003) Essential oil analysis and antimicrobial activity of eight Stachys species from Greece. Phytochemistry, 64, 743–752.
7.
SkaltsaHD, LazariDM, ChinouIB, LoukisAE. (1999) Composition and antibacterial activity of the essential oils of Stachys candida and S. chrysantha from southern Greece. Planta Medica, 65, 255–256.
8.
StamatisG, KyriazopoulosP, GolegouS, BasayiannisA, SkaltsasS, SkaltsaH. (2003) In vitro anti-Helicobacter pylori activity of Greek herbal medicines. Journal of Ethnopharmacology, 88, 175–179.
9.
Lamer-ZarawskaE, Rzadkowska-BodalskaH, KarlowiczK. (1992) Antifungal activity of some medicinal plants of the Lamiaceae family. Bulletin of the Polish Academy of Sciences: Biological Sciences, 39, 387–393.
10.
HayashiK, NagamatsuT, ItoM, HattoriT, SuzukiY. (1994) Acetoside, a component of Stachys sieboldii Miq, may be a promising antinephritic agent: effect of acteoside on crescentic-type anti-GBM nephritis in rats. Japanese Journal of Pharmacology, 65, 143–151.
11.
HayashiK, NagamatsuT, ItoM, HattoriT, SuzukiY. (1994) Acteoside, a component of Stachys sieboldii Miq, may be a promising antinephritic agent (2): Effect of acteoside on leukocyte accumulation in the glomeruli of nephritic rats. Japanese Journal of Pharmacology, 66, 47–52.
12.
HayashiK, NagamatsuT, ItoM, YagitaH, SuzukiY. (1996) Acteoside, a component of Stachys sieboldii Miq, may be a promising antinephritic agent (3): effect of aceteoside on expression of intercellular adhesion molecule-1 in experimental nephritic glomeruli in rats and cultured endothelial cells. Japanese Journal of Pharmacology, 70, 157–168.
13.
CouladisM, TzakouO, VerykokidouE, HarvalaC. (2003) Screening of some Greek aromatic plants for antioxidant activity. Phytotherapy Research: PTR, 17, 194–195.
14.
For example: NakagawaH, TakaishiY, TanakaN, TsuchiyaK, ShibataH, HigutiT. (2006) Chemical constituents from the peels of Citrus sudachi.Journal of Natural Products, 69, 1177–1179.
15.
For example: GuanW, LiS, YanR, HuangY. (2006) Comparison of composition and antifungal activity of Artemisia argyi Levl. et Vant inflorescence essential oil extracted by hydrodistillation and supercritical carbon dioxide. Natural Products Research, Part B: Bioactive Natural Products, 20, 992–998.
16.
ReynoldsWF, McLeanS, TayL-L, YuM, EnriquezRG, EstwickDM, PascoeKO. (1997) Comparison of 13C resolution and sensitivity of HSQC and HMQC sequences and application of HSQC-based sequences to the total 1H and 13C spectral assignment of clionasterol. Magnetic Resonance in Chemistry, 35, 455–462.
17.
SangS, KikuzakiH, LapsleyK, RosenRT, NakataniN, HoC-T. (2002) Sphingolipid and other constituents from nuts (Prunus amygdalus Batsch). Journal of Agricultural and Food Chemistry, 50, 4709–4712.
18.
MahatoSB, KunduAP. (1994) 13C NMR spectra of pentacyclic triterpenoids – compilation and some salient features. Phytochemistry, 37, 1517–1575.
19.
MunehisaA, ToshitakaH, YoshikoN, MotohiroT, TakumaS. (1997) Cytotoxic principles from Chrysosplenium flagelliferum. International Journal of Pharmacognosy, 35, 141–143.
