Abstract
Cleome viscosa (Capparidaceae) is used in fever, inflammation and liver diseases. Systematic investigation of the seeds of this species has resulted in the isolation of three coumarinolignoids, cleomiscosin A, B and C. The present study was undertaken to determine the immunomodulatory activity of these coumarinolignoids using inbred female Swiss albino mice as an in-vivo study. Experimental animals were divided into six groups, each comprised of six mice. These received oral treatment for a period of 28 days. Body weight variation, and hematological, humoral and cell mediated immune response related parameters were studied in which coumarinolignoids at a dose of 10 mg/kg body weight enhanced the body immune function by significantly increasing the white blood cell count, hemagglutination antibody titer responses, and reducing delayed type hypersensitivity response towards rabbit red blood cells.