A chemical study of the bark of Sapium hippomane (Euphorbiaceae), obtained in the parish of St. John, Barbados, led to the isolation of two new phorbol esters (1 and 2), in addition to the known compound 4-deoxyphorbol (3). Compounds 1 and 2 were C-4 epimers, with a tigliane-type skeleton possessing C5 esters at C-12 and C-13. Chromatographic methods were utilized to separate the compounds and their structures determined through interpretation of physical data.
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