Phytochemical investigation of the latex of Euphorbia abyssinica Gmel (Euphorbiaceae) afforded a new hydroxy unsaturated fatty acid, 8(R)-hydroxy-dec-3(E)-en-oic acid (1), in addition to the four known compounds lupeol (2), β-sitosterol (3), oleanolic acid (4) and β-sitosterol-3-O-glucoside (5). The in vitro antibacterial and antifungal activities of the isolated compounds, as well as the total methanol extract, were studied against different micro-organisms; compound 1 displayed reasonable antifungal activities towards the tested fungi.
YoussoufMS, KaiserP, TahirM, SinghGD, SinghS, SharmaVK, SattiNK, HaqueSE, JohriRK. (2007) Anti-anaphylactic effect of Euphorbia hirta. Fitoterapia, 78, 535–539.
2.
BarlaA, OztürkM, KültürS, OksüzS. (2007) Screening of antioxidant activity of three Euphorbia species from Turkey. Fitoterapia, 78, 423–425.
3.
ZhangWK, XuJK, ZhangXQ, YaoXS, YeWC. (2007) Sphingolipids with neuritogenic activity from Euphorbia sororia. Chemistry and Physics of Lipids, 148, 77–83.
4.
DaoubiM, MarquezN, MazoirN, BenharrefA, HernandezGR, MunozE, CalladoIG. (2007) Isolation of new phenylacetylingol derivatives that reactivate HIV-1 latency and a novel spirotriterpenoid from Euphorbia officinarum latex. Bioorganic & Medicinal Chemistry, 15, 4577–4584.
5.
BaniS, KaulA, KhanB, GuptaVK, SattiNK, SuriKA, QaziGN. (2007) Anti-arthritic activity of a biopolymeric fraction from Euphorbia tirucalli. Journal of Ethnopharmacology, 110, 92–98.
6.
BaniS, KaulA, JaggiBS, SuriKA, SuriOP, SharmaOP. (2000) Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex. Fitoterapia, 71, 655–662.
7.
TiwariS, SinghA. (2004) Piscicidal and anti-acetylcholinesterase activity of Euphorbia royleana stem bark extracts against freshwater common predatory fish Channa punctatus. Environmental Toxicology and Pharmacology, 18, 47–53.
8.
MiriR, JavidniaK, JafariA. (2003) Cytotoxicity and antimicrobial activity of Euphorbia hebecarpa Boiss. Toxicology Letters, 144, 88.
9.
JassbiAR. (2006) Chemistry and biological activity of secondary metabolites in Euphorbia from Iran. Phytochemistry, 67, 1977–1984.
10.
ZirihiGN, MamboL, GuinaFG, BodoB, GrellierP. (2005) In vitro antiplasmodium activity and cytotoxicity of 33 West African plants used for treatment of malaria. Journal of Ethnopharmacology, 98, 281–285.
11.
NatarajanD, BrittoSJ, SrinivasanK, NagamuruganN, MohanasundariC, PerumalG. (2005) Anti-bacterial activity of Euphorbia fusiformis—A rare medicinal herb. Journal of Ethnopharmacology, 102, 123–126.
12.
ValenteC, FerreiraMJ, AbreuPM, GyémántN, UgocsaiK, HohmannJ, MolnárJ. (2004) Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells. Planta Medica, 70, 81–84.
13.
GaoS, LiuHY, WangYH, HeHP, WangJS, DiYT, LiCS, FangX, HaoXJ. (2007) Lathyranone A: a diterpenoid possessing an unprecedented skeleton from Euphorbia lathyris. Organic Letters, 9, 3453–3455.
14.
HabaH, LavaudC, HarkatH, Alabdul MagidA, MarcourtL, BenkhaledM. (2007) Diterpenoids and triterpenoids from Euphorbia guyoniana. Phytochemistry, 68, 1255–1260.
15.
RavikanthV, LakshmiNRV, VijenderRA, RavinderK, PrabhakarRT, SivaRT, AnandKK, PrakeshVD, VenkateswarluY. (2003) Three new ingol diterpenes from Euphorbia nivulia: Evaluation of cytotoxic activity. Chemical & Pharmaceutical Bulletin, 51, 431–434.
16.
Betancur-GalvisL, PalomaresE, MarcoJA, EstornellE. (2003) Tigliane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain. Journal of Ethnopharmacology, 85, 279–282.
17.
DuarteN, FerreiraMU. (2007) Lagaspholones A and B: two new jatropholane-type diterpenes from Euphorbia lagascae. Organic Letters, 9, 489–492.
18.
VasasA, HohmannJ, ForgoP, SzaboP. (2004) New tri- and tetracyclic diterpenes from Euphorbia villosa. Tetrahedron, 60, 5025–5030.
YoshikawaM, ShimadaH, MatsudaH, YamaharaJ, MurakamiN. (1996) Bioactive constituents of Chinese natural medicines. I. New sesquiterpene ketones with vasorelaxant effect from Chinese Moxa, the processed leaves of Aetemisia argyi Levl et Vant: moxartenone and moxartenolide. Chemical & Pharmaceutical Bulletin, 44, 1656–1662.
21.
SeoY, ChoKW, LeeHS, RhoJR, ShinJ. (1999) New acetylenic enol ethers of glycerol from the sponge Petrosia sp. Journal of Natural Products, 62, 122–126.
22.
JenniferMA. (2001) Determination of MIC. Journal of Antimicrobial Chemotherapy, 48, 5–16.
23.
BauerAW, KirbyWM, SherrisJC, TurkM. (1996) Antibiotic susceptibility testing by a standard single disc method. Analytical Journal of Clinical Pathology, 45, 493–496.