Sage Journals: Discover world-class research

Abstract

Keywords

alginate anti-inflammatory drugs controlled release glucose sensing layer-by-layer self-assembly

The following article has been retracted at the request of the Journal Editor and Sage:

Srivastava R, Jayant RD, Chaudhary A, McShane MJ. “Smart Tattoo” glucose biosensors and effect of coencapsulated anti-inflammatory agents. J Diabetes Sci Technol. 2011;5(1):76-85. doi: 10.1177/193229681100500111

Sage was contacted by a reader with concerns about potential image duplication and unattributed overlap to another publication. Sage was also alerted to a conversation on PubPeer highlighting additional image concerns.

Concerns were raised about the following figures in the article:

a) Figure 1A contains signs of in-image duplicate and appears highly similar to Figure 1A [1].

b) Figure 6, images labelled Plain MS, Day 7 and Day 28, appear highly similar to Figure 4, 1A and 1B [1].

c) Figure 6, images labelled Dexamethasone-loaded MS, Day 7 and Day 28, appear highly similar to Figure 4, 1C and 1D [1].

d) Figure 6, images labelled Dexamethasone-loaded MS, Day 7 and Day 28, appear highly similar to Figure 4, 1C and 1D [1].

e) Figure 6, images labelled Diclofenac-loaded MS, Day 7 and Day 28, appears highly similar to Figure 5, 1C and 1D [1].

f) Figure 7A, image labelled Plain GOx Sensor, Day 7, appears highly similar to Figure 4, 2B [1].

g) Figure 7A, image labelled Plain GOx Sensor, Day 28, appears highly similar to Figure 4, 2A [1].

h) Figure 7C, image labelled GOx sensor + dexamethasone, Day 7, appears highly similar to Figure 4, 2D [1].

i) Figure 7C, image labelled GOx sensor + dexamethasone, Day 28, appears highly similar to Figure 4, 2C [1].

j) Figure 7D, images labelled GOx sensor + diclofenac, Day 7 and Day 28, appear highly similar to Figure 5, 2C and 2D [1].

The article also contains substantial unreferenced overlap:

a) Figure 4A and 4B duplicates data from Figure 2, split across two figures [1].

b) Data for ‘Uncoated MS’, Figure 5, contains some of the same data as Figure 3 [1].

c) Unattributed text overlap with other articles [1], [2], [3] by the same author group.

The authors were unable to provide the uncropped raw images and raw data underlying the figures.

The authors acknowledged the reuse of images in Figure 1A, Figure 6, Figure 7A/C/D and explained that any text overlap was due to an error. The authors requested to correct the article with appropriate attribution.

The Journal Editor evaluated the response and deemed the articles to contain significant overlap and image duplication. Because of the unresolved concerns about the image integrity that call into question the validity of the findings the Journal Editor and Sage retracts the article.

R. S. disagreed with the decision to retract. The remaining authors did not respond when notified.

References

1. Jayant RD, McShane MJ, Srivastava R. In vitro and in vivo evaluation of anti-inflammatory agents using nanoengineered alginate carriers: towards localized implant inflammation suppression. Int J Pharm. 2011 Jan 17;403 (1–2): 268-75.

2. Chaudhary A, Harma H, Hanninen P, McShane MJ, Srivastava R. Glucose response of near-infrared alginate-based microsphere sensors under dynamic reversible conditions. Diabetes Technol Ther. 2011 Aug;13(8):827-35.

3. Chaudhary A, Raina M, Harma H, Hanninen P, McShane MJ, Srivastava R. Evaluation of glucose sensitive affinity binding assay entrapped in fluorescent dissolved-core alginate microspheres. Biotechnol Bioeng. 2009 Dec 15;104(6): 1075-85.

References

Clarke

Anderson

Breton

Patek

Kashmer

Kovatchev

. Closed-loop artificial pancreas using subcutaneous glucose sensing and insulin delivery and a model predictive control algorithm: The Virginia experience. J Diabetes Sci Technol. 2009; 3 (5): 1031–8.

Valdes

Moussy

. In vitro and in vivo degradation of glucose oxidase enzyme used for an implantable glucose biosensor. Diabetes Technol Ther. 2000; 2 (3): 367–76.

Pickup

Rolinski

Birch

. In vivo glucose sensing for diabetes management: Progress towards non-invasive monitoring. BMJ. 1999; 319 (7220): 1289.

Pickup

Hussain

Evans

Sachedina

. In vivo glucose monitoring: The clinical reality and the promise. Biosens Bioelectron. 2005; 20 (10): 1897–902.

Gerritsen

Jansen

Lutterman

. Performance of subcutaneously implanted glucose sensors for continuous monitoring. Neth J Med. 1999; 54 (4): 167–79.

Wickramasinghe

Yang

Spencer

. Current problems and potential techniques in in vivo glucose monitoring. J Fluoresc. 2004; 14 (5): 513–20.

Pickup

Hussain

Evans

Rolinski

Birch

. Fluorescence-based glucose sensors. Biosens Bioelectron. 2005; 20 (12): 2555–65.

Hughes

. The business of self-monitoring of blood glucose: A market profile. J Diabetes Sci Technol. 2009; 3 (5): 1219–23.

McShane

. Potential for glucose monitoring with nanoengineered fluorescent biosensors. Diabetes Technol Ther. 2002; 4 (4): 533–8.

10.

Brown

McShane

. Modeling of spherical fluorescent glucose microsensor systems: Design of enzymatic smart tattoos. Biosens Bioelectron. 2006; 21 (9): 1760–9.

11.

Brown

Srivastava

Zhu

McShane

. Enzymatic fluorescent microsphere glucose sensors: Evaluation of response under dynamic conditions. Diabetes Technol Ther. 2006; 8 (3): 288–95.

12.

Chinnayelka

McShane

. Microcapsule biosensors using competitive binding resonance energy transfer assays based on apoenzymes. Anal Chem. 2005; 77 (17): 5501–11.

13.

Stein

Grant

Zhu

McShane

. Microscale enzymatic optical biosensors using mass transport limiting nanofilms. 1. Fabrication and characterization using glucose as a model analyte. Anal Chem. 2007; 79 (4): 1339–48.

14.

Freeland

Bonnecaze

. Inference of blood glucose concentrations from subcutaneous glucose concentrations: Applications to glucose biosensors. Ann Biomed Eng. 1999; 27 (4): 525–37.

15.

Thennadil

Rennert

Wenzel

Hazen

Ruchti

Block

. Comparison of glucose concentration in interstitial fluid, and capillary and venous blood during rapid changes in blood glucose levels. Diabetes Technol Ther. 2001; 3 (3): 357–65.

16.

Caplin

O'Leary

Bulsara

Davis

Jones

. Subcutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycaemia. Diabet Med. 2003; 20 (3): 238–41.

17.

McShane

Rastegar

Pishko

Coté

. Monte Carlo modeling for implantable fluorescent analyte sensors. IEEE Trans Biomed Eng. 2000; 47 (5): 624–32.

18.

Long

McShane

. Optical instrument design for interrogation of dermally-implanted luminescent microparticle sensors. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008: 5656–9.

19.

Onuki

Bhardwaj

Papadimitrakopoulos

Burgess

. A review of the biocompatibility of implantable devices: Current challenges to overcome foreign body response. J Diabetes Sci Technol. 2008; 2 (6): 1003–15.

20.

Buckingham

Caswell

Wilson

. Real-time continuous glucose monitoring. Curr Opin Endocrinol Diabetes Obes. 2007; 14 (4): 288–95.

21.

Wisniewski

Reichert

. Methods for reducing biosensor membrane biofouling. Colloids Surf B Biointerfaces. 2000; 18 (3–4): 197–219.

22.

Norton

Tegnell

Toporek

Reichert

. In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. Biomaterials. 2005; 26 (16): 3285–97.

23.

Bhardwaj

Sura

Papadimitrakopoulos

Burgess

. Controlling acute inflammation with fast releasing dexamethasone-PLGA microsphere/PVA hydrogel composites for implantable devices. J Diabetes Sci Techonol. 2007; 1 (1): 8–17.

24.

Galeska

Kim

Patil

Bhardwaj

Chatttopadhyay

Papadimitrakopoulos

Burgess

. Controlled release of dexamethasone from PLGA microspheres embedded within polyacid-containing PVA hydrogels. AAPS J. 2005; 7 (1): E231–40.

25.

Zolnik

Burgess

. Evaluation of in vivo-in vitro release of dexamethasone from PLGA microspheres. J Control Release. 2008; 127 (2): 137–45.

26.

Decher

Lehr

Lowack

Lvov

Schmitt

. New nano-composite films for biosensors: Layer-by-layer adsorbed films of poly-electrolytes, proteins or DNA. Biosens Bioelectron. 1994; 9 (9–10): 677–84.

27.

Decher

Lvov

Schmitt

. Proof of multilayer structural organization in self-assembled polycation- polyanion molecular films. Thin Solid Films. 1994; 244 (1–2): 772–77.

28.

Swoboda

. The relationship between molecular conformation and the binding of flavin-adenine dinucleotide in glucose oxidase. Biochim Biophys Acta. 1969; 175 (2): 365–79.

29.

Chaudhary

Srivastava

. Glucose sensing using competitive binding assay co-encapsulated in uniform sized alginate microspheres. Sens Lett. 2008; 6 (2): 253–60.

30.

Chaudhary

Raina

Harma

Hanninen

McShane

Srivastava

. Evaluation of glucose sensitive affinity binding assay entrapped in fluorescent dissolved-core alginate microspheres. Biotechnol Bioeng. 2009; 104 (6): 1075–85.

31.

Chinnayelka

McShane

. Resonance energy transfer nanobiosensors based on affinity binding between Apo-enzyme and its substrate. Biomacromolecules. 2004; 5 (5): 1657–61.

32.

Doherty

Humphreys

. Fluid and electrolyte management. In: Doherty

Way

, ed. Current surgical diagnosis and treatment. 12th ed. New York: McGraw-Hill; 2006, 127–39.

33.

Jayant

Srivastava

. Dexamethasone release from uniform sized nanoengineered alginate microspheres. J Biomed Nanotechnol. 2007; 3 (3): 1–9.

34.

Jayant

McShane

Srivastava

. Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release. Drug Deliv. 2009; 16 (6): 331–40.

RETRACTED: “Smart Tattoo” Glucose Biosensors and Effect of Coencapsulated Anti-Inflammatory Agents

Abstract

Keywords

References