Neurotrophic receptors are specialized proteins on the surface of neurons that regulate the growth, development, and survival of nerve cells, interacting with specific neurotrophic factors to support neuronal function and overall brain health. Key examples include the tropomyosin receptor kinase (Trk) family and the p75 neurotrophin receptor. This review highlights the neuroprotective potential of berries such as blueberries, strawberries, raspberries, and blackberries known for their rich content of bioactive compounds, including polyphenols, flavonoids, and anthocyanins. These phytochemicals possess antioxidant and anti-inflammatory properties that may play a critical role in neuroprotection. Emerging evidence from clinical trials suggests that berry consumption can enhance cognitive function and provide protection against age-related neurodegenerative diseases. Notably, the modulation of signaling pathways related to neurotransmission, cell survival, inflammation, and neuroplasticity underscores the significance of these fruits in neuroprotection. This review uniquely synthesizes recent findings on the specific neurotrophic factors influenced by berry-derived phytochemicals, providing insights into their mechanisms of action. Furthermore, we explore the implications of these compounds in developing functional foods aimed at preventing neurodegeneration and promoting cognitive health, thereby contributing to the growing body of research on dietary interventions for brain health.
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