The pathogenesis of osteoarthritis (OA) appears to be the result of a complex
interplay between mechanical, cellular, and biochemical forces. Obesity is the
strongest risk factor for disease onset and mechanical factors dominate the risk for
disease progression. This narrative review focuses on the influence of biomechanics
and obesity on the etiology of OA and its symptomatic presentation. We need to
revisit the way we currently manage the disease and focus on the modifiable,
primarily through nonpharmacologic intervention. Greater therapeutic attention to
the important role of mechanical factors and obesity in OA etiopathogenesis is
required if we are to find ways of reducing the public health impact of this
condition.
( 1994)
Arthritis prevalence and activity limitations-United States
, 1990. MMWR Morb Mortal Wkly Rep43: 433-438.
2.
( 1998)
Prevalence and impact of chronic joint symptoms-seven states
, 1996. MMWR Morb Mortal Wkly Rep47: 345-351.
3.
( 2001)
Prevalence of disabilities and associated health conditions among
adults-United States
, 1999. MMWR Morb Mortal Wkly Rep50: 120-125.
4.
( 2005)
Review: Both aerobic and home-based quadriceps strengthening exercises
reduce pain and disability in knee osteoarthritis
. ACP Journal Club143:
71
.
5.
(2009) Guideline on the Treatment of Osteoarthritis (OA) of the Knee.
Internet Communication.
6.
Abramson, S.B.
,
Attur, M.
and
Yazici, Y.
( 2006)
Prospects for disease modification in osteoarthritis
. Nat Clin Pract Rheumatol2: 304-312.
7.
American Academy of Orthopaedic Surgeons (AAOS)
( 2008) Treatment of osteoarthritis of the knee
(nonarthroplasty) .
Rosemont
(IL):
American Academy of Orthopaedic Surgeons
. p. 263.
8.
Amin, S.
,
LaValley, M.P.
,
Guermazi, A.
,
Grigoryan, M.
,
Hunter, D.J.
,
Clancy, M.
et al. (2005)
The relationship between cartilage loss on magnetic resonance imaging and
radiographic progression in men and women with knee osteoarthritis
. Arthritis Rheum52: 3152-3159.
9.
Andriacchi, T.P.
( 1994)
Dynamics of knee malalignment
. Orthop Clin North Am25: 395-403.
10.
Andriacchi, T.P.
,
Mundermann, A.
,
Smith, R.L.
,
Alexander, E.J.
,
Dyrby, C.O.
and
Koo, S.
( 2004)
A framework for the in vivo pathomechanics of osteoarthritis at the
knee
. Ann Biomed Eng32: 447-457.
11.
Anonymous
(2000)
Recommendations for the medical management of osteoarthritis of the hip and
knee: 2000 update. American College of Rheumatology Subcommittee on
Osteoarthritis Guidelines
. Arthritis Rheum43: 1905-1915.
12.
Balint, G.
,
Rooney, P.J.
and
Buchanan, W.W.
( 1987)
A legacy for rheumatology from Sir William Osler
. Clin Rheumatol6: 423-435.
13.
Baratz, M.E.
,
Fu, F.H.
and
Mengato, R.
( 1986)
Meniscal tears: the effect of meniscectomy and of repair on intraarticular
contact areas and stress in the human knee. A preliminary report
. Am J Sports Med14: 270-275.
14.
Bellamy, E.
,
Wilson, C.
and
Bellamy, N.(2009) Osteoarthritis measurement in routine rheumatology outpatient
practice (OMIRROP) in Australia: A survey of practice style, instrument use,
responder criteria, and state-attainment criteria
. J Rheumatol36(5):
1049-1055.
15.
Bhattacharyya, T.
,
Gale, D.
,
Dewire, P.
,
Totterman, S.
,
Gale, M.E.
,
McLaughlin, S.
et al. (2003)
The clinical importance of meniscal tears demonstrated by magnetic
resonance imaging in osteoarthritis of the knee
. J Bone Joint Surg Am85-A: 4-9.
16.
Blin, O.
,
Pailhous, J.
,
Lafforgue, P.
and
Serratrice, G.
( 1990)
Quantitative analysis of walking in patients with knee osteoarthritis: a
method of assessing the effectiveness of non-steroidal anti-inflammatory
treatment
. Ann Rheum Dis49: 990-993.
17.
Brandt, K.D.
,
Radin, E.L.
,
Dieppe, P.A.
and
Van De, P.L.
( 2006)
Yet more evidence that osteoarthritis is not a cartilage disease
. Ann Rheum Dis65: 1261-1264.
18.
Brinker, M.R.
,
O’Connor, D.P.
,
Pierce, P.
,
Woods, G.W.
and
Elliott, M.N.
( 2002)
Utilization of orthopaedic services in a capitated population
. J Bone Joint Surg Am84-A: 1926-1932.
19.
Carter, D.R.
,
Beaupre, G.S.
,
Wong, M.
,
Smith, R.L.
,
Andriacchi, T.P.
and
Schurman, D.J.
( 2004)
The mechanobiology of articular cartilage development and
degeneration
. Clin Orthop Relat ResS69-S77.
20.
Centers for Disease Control and Prevention (CDC).
( 2007)
National and state medical expenditures and lost earnings attributable to
arthritis and other rheumatic conditions-United States, 2003
. MMWR Morb Mortal Wkly Rep56: 4-7.
21.
Cerejo, R.
,
Dunlop, D.D.
,
Cahue, S.
,
Channin, D.
,
Song, J.
and
Sharma, L.
( 2002)
The influence of alignment on risk of knee osteoarthritis progression
according to baseline stage of disease
. Arthritis Rheum46: 2632-2636.
22.
Chard, J.
,
Dickson, J.
,
Tallon, D.
and
Dieppe, P.
( 2002)
A comparison of the views of rheumatologists, general practitioners and
patients on the treatment of osteoarthritis
. Rheumatology41: 1208-1210.
23.
Chassany, O.
,
Boureau, F.
,
Liard, F.
,
Bertin, P.
,
Serrie, A.
,
Ferran, P.
et al. (2006)
Effects of training on general practitioners’ management of pain
in osteoarthritis: a randomized multicenter study
. J Rheumatol33: 1827-1834.
24.
Clegg, D.O.
,
Reda, D.J.
,
Harris, C.L.
,
Klein, M.A.
,
O’Dell, J.R.
,
Hooper, M.M.
et al. (2006)
Glucosamine, chondroitin sulfate, and the two in combination for painful
knee osteoarthritis
. N Eng J Med354: 795-808.
25.
Coggon, D.
,
Reading, I.
,
Croft, P.
,
McLaren, M.
,
Barrett, D.
,
Cooper, C.
et al. (2001)
Knee osteoarthritis and obesity
. Int J Obes Relat Metab Disord25: 622-627.
26.
Cooperman, D.R.
,
Wallensten, R.
and
Stulberg, S.D.
( 1983)
Acetabular dysplasia in the adult
. Clin Orthop Relat Res175: 79-85.
27.
DeHaan, M.N.
,
Guzman, J.
,
Bayley, M.T.
and
Bell, M.J.
( 2007)
Knee osteoarthritis clinical practice guidelines - how are we doing
? J Rheumatol34: 2099-2105.
28.
Denoeud, L.
,
Mazieres, B.
,
Payen-Champenois, C.
and
Ravaud, P.
( 2005)
First line treatment of knee osteoarthritis in outpatients in France:
adherence to the EULAR 2000 recommendations and factors influencing
adherence
. Ann Rheum Dis64: 70-74.
29.
Dieppe, P.A.
and
Lohmander, L.S.
( 2005)
Pathogenesis and management of pain in osteoarthritis
. Lancet365: 965-973.
30.
Draper, E.R.
,
Cable, J.M.
,
Sanchez-Ballester, J.
,
Hunt, N.
,
Robinson, J.R.
and
Strachan, R.K.
( 2000)
Improvement in function after valgus bracing of the knee. An analysis of
gait symmetry
. J Bone Joint Surg Br82: 1001-1005.
31.
Dunlop, D.D.
,
Manheim, L.M.
,
Song, J.
and
Chang, R.W.
( 2001)
Arthritis prevalence and activity limitations in older adults
. Arthritis Rheum44: 212-221.
32.
Elahi, S.
,
Cahue, S.
,
Felson, D.T.
,
Engelman, L.
and
Sharma, L.
( 2000)
The association between varus-valgus alignment and patellofemoral
osteoarthritis
. Arthritis Rheum43: 1874-1880.
33.
Englund, M.
,
Guermazi, A.
,
Gale, D.
,
Hunter, D.J.
,
Aliabadi, P.
,
Clancy, M.
et al. (2008)
Incidental meniscal findings on knee MRI in middle-aged and elderly
persons
. N Eng J Med359: 1108-1115.
34.
Ettinger, W.H.J.
,
Burns, R.
,
Messier, S.P.
,
Applegate, W.
,
Rejeski, W.J.
,
Morgan, T.
et al. (1997)
A randomized trial comparing aerobic exercise and resistance exercise with
a health education program in older adults with knee osteoarthritis. The
Fitness Arthritis and Seniors Trial (FAST)
. JAMA277: 25-31.
35.
Eyre, D.R.
( 2004)
Collagens and cartilage matrix homeostasis
. Clin Orthop Relat Res
S118-122.
36.
Felson, D.T.
( 2004a)
An update on the pathogenesis and epidemiology of osteoarthritis
. Radiol Clin North Am42: 1-9.
37.
Felson, D.T.
( 2004b)
Risk factors for osteoarthritis: understanding joint vulnerability
. Clin Orthop Relat Res
S16-21.
38.
Felson, D.T.
,
Goggins, J.
,
Niu, J.
,
Zhang, Y.
and
Hunter, D.J.
( 2004)
The effect of body weight on progression of knee osteoarthritis is
dependent on alignment
. Arthritis Rheum50: 3904-3909.
39.
Felson, D.T.
,
Lawrence, R.C.
,
Hochberg, M.C.
,
McAlindon, T.
,
Dieppe, P.A.
,
Minor, M.A.
et al. (2000)
Osteoarthritis: new insights. Part 2: treatment approaches
. Ann Intern Med133: 726-737.
40.
Felson, D.T.
and
Zhang, Y.
( 1998)
An update on the epidemiology of knee and hip osteoarthritis with a view to
prevention
. Arthritis Rheum41: 1343-1355.
41.
Ficat, P.
( 1978)
[The syndrome of lateral hyperpressure of the patella]. [French]
. Acta Orthop Belg44: 65-76.
42.
Ficat, R.P.
and
Hungerford, D.S.
( 1977) Disorders of the Patello-femoral Joint,
The Williams and Wilkins Co.:
Baltimore .
43.
Flegal, K.M.
,
Carroll, M.D.
,
Ogden, C.L.
,
Johnson, C.L.
,
Flegal, K.M.
,
Carroll, M.D.
et al. (2002)
Prevalence and trends in obesity among US adults, 1999-2000
. JAMA288: 1723-1727.
44.
Fukubayashi, T.
and
Kurosawa, H.
( 1980)
The contact area and pressure distribution pattern of the knee. A study of
normal and osteoarthrotic knee joints
. Acta Orthop Scand51: 871-879.
45.
Gardiner, P.
,
Graham, R.
,
Legedza, A.T.
,
Ahn, A.C.
,
Eisenberg, D.M.
and
Phillips, R.S.
( 2007)
Factors associated with herbal therapy use by adults in the United
States
. Altern Ther Health Med13: 22-29.
46.
Glazier, R.H.
,
Dalby, D.M.
,
Badley, E.M.
,
Hawker, G.A.
,
Bell, M.J.
,
Buchbinder, R.
et al. (1998)
Management of common musculoskeletal problems: a survey of Ontario primary
care physicians
. CMAJ158: 1037-1040.
47.
Goodman, D.A.
,
Feighan, J.E.
,
Smith, A.D.
,
Latimer, B.
,
Buly, R.L.
and
Cooperman, D.R.
( 1997)
Subclinical slipped capital femoral epiphysis. Relationship to
osteoarthrosis of the hip
. J Bone Joint Surg Am79: 1489-1497.
48.
Grelsamer, R.P.
and
Weinstein, C.H.
( 2001)
Applied biomechanics of the patella
. Clin Orthop Relat Res389: 9-14.
49.
Gross, K.D.
and
Hillstrom, H.J.
( 2008)
Noninvasive devices targeting the mechanics of osteoarthritis
. Rheum Dis Clin North Am34: 755-776.
50.
Guccione, A.A.
,
Felson, D.T.
,
Anderson, J.J.
,
Anthony, J.M.
,
Zhang, Y.
,
Wilson, P.W.
et al. (1994)
The effects of specific medical conditions on the functional limitations of
elders in the Framingham Study
. Am J Public Health84: 351-358.
51.
Hall, M.J.
and
Lawrence, L.
( 1998)
Ambulatory surgery in the United States
, 1996. Adv Data300: 1-16.
52.
Hannan, M.T.
,
Felson, D.T.
and
Pincus, T.
( 2000)
Analysis of the discordance between radiographic changes and knee pain in
osteoarthritis of the knee
. J Rheumatol27: 1513-1517.
53.
Harris, W.H.
( 1986)
Etiology of osteoarthritis of the hip
. Clin Orthop Relat Res213: 20-33.
54.
Harrison, M.M.
,
Cooke, T.D.
,
Fisher, S.B.
and
Griffin, M.P.
( 1994)
Patterns of knee arthrosis and patellar subluxation
. Clin Orthop Relat Res309: 56-63.
55.
Hassan, B.S.
,
Doherty, S.A.
,
Mockett, S.
and
Doherty, M.
( 2002)
Effect of pain reduction on postural sway, proprioception, and quadriceps
strength in subjects with knee osteoarthritis
. Ann Rheum Dis61: 422-428.
56.
Hewett, T.E.
( 2000)
Neuromuscular and hormonal factors associated with knee injuries in female
athletes. Strategies for intervention
. Sports Med29: 313-327.
57.
Hinman, R.S.
,
Crossley, K.M.
,
McConnell, J.
and
Bennell, K.L.
( 2003)
Efficacy of knee tape in the management of osteoarthritis of the knee:
blinded randomised controlled trial
. BMJ327:
135
.
58.
Hunter, D.J.
,
Niu, J.
,
Zhang, Y.
,
Totterman, S.
,
Tamez-Pena, J.
,
Dabrowski, C.
et al. (2008a)
Change in Cartilage Morphometry: a sample of the progression cohort of the
Osteoarthritis Initiative
. Ann Rheum Dis68: 349-356.
59.
Hunter, D.J.
and
Hellio LeGraverand-Gastineau, M.P.
( 2008)
How close are we to having structure-modifying drugs available?Rheum Dis Clin North Am34: 789-802.
60.
Hunter, D.J.
,
McDougall, J.J.
and
Keefe, F.J.
( 2008b)
The symptoms of osteoarthritis and the genesis of pain
. Rheum Dis Clin North Am34: 623-643.
61.
Hunter, D.J.
,
Patil, V.
,
Niu, J.B.
,
McLennan, C.
,
LaValley, M.
,
Genant, H.
et al. (2004)
The etiology of knee pain in the community
. Arthritis Rheum50:
1885
.
62.
Hunter, D.J.
,
Zhang, Y.Q.
,
Niu, J.B.
,
Felson, D.T.
,
Kwoh, K.
,
Newman, A.
et al. (2007)
Patella malalignment, pain and patellofemoral progression: the Health ABC
Study
. Osteoarthritis Cartilage15: 1120-1127.
63.
Hunter, D.
( 2007)
In the clinic. Osteoarthritis
. Ann Intern Med147: ITC8-16.
64.
Hunter, D.
and
Felson, D.
( 2006)
Osteoarthritis
. BMJ332: 639-642.
65.
Hurley, M.V.
( 1999)
The role of muscle weakness in the pathogenesis of osteoarthritis
. Rheum Dis Clin North Am25: 283-298.
66.
Hurwitz, D.E.
,
Ryals, A.B.
,
Case, J.P.
,
Block, J.A.
and
Andriacchi, T.P.
( 2002)
The knee adduction moment during gait in subjects with knee osteoarthritis
is more closely correlated with static alignment than radiographic disease
severity, toe out angle and pain
. J Orthop Res20: 101-107.
67.
Huskisson, E.C.
,
Berry, H.
,
Gishen, P.
,
Jubb, R.W.
and
Whitehead, J.
( 1995)
Effects of antiinflammatory drugs on the progression of osteoarthritis of
the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal
Antiinflammatory Drugs in Knee Osteoarthritis
. J Rheumatol22: 1941-1946.
68.
Huston, L.J.
,
Greenfield, M.L.
and
Wojtys, E.M.
( 2000)
Anterior cruciate ligament injuries in the female athlete. Potential risk
factors
. Clin Orthop Relat Res372: 50-63.
69.
Hutchings, A.
,
Calloway, M.
,
Choy, E.
,
Hooper, M.
,
Hunter, D.J.
,
Jordan, J.M.
et al. (2007)
The Longitudinal Examination of Arthritis Pain (LEAP) study: Relationships
between weekly fluctuations in patient-rated joint pain and other health
outcomes
. J Rheumatol34: 2291-2300.
70.
Iwano, T.
,
Kurosawa, H.
,
Tokuyama, H.
and
Hoshikawa, Y.
( 1990)
Roentgenographic and clinical findings of patellofemoral osteoarthrosis.
With special reference to its relationship to femorotibial osteoarthrosis
and etiologic factors
. Clin Orthop Relat Res252: 190-197.
Jawad, A.S.
( 2005)
Analgesics and osteoarthritis: are treatment guidelines reflected in
clinical practice
? Am J Ther12: 98-103.
73.
Jordan, K.M.
,
Arden, N.K.
,
Doherty, M.
,
Bannwarth, B.
,
Bijlsma, J.W.
,
Dieppe, P.
et al. (2003)
EULAR Recommendations 2003: an evidence based approach to the management of
knee osteoarthritis: Report of a Task Force of the Standing Committee for
International Clinical Studies Including Therapeutic Trials (ESCISIT)
. Ann Rheum Dis62: 1145-1155.
74.
Jordan, K.M.
,
Sawyer, S.
,
Coakley, P.
,
Smith, H.E.
,
Cooper, C.
and
Arden, N.K.
( 2004)
The use of conventional and complementary treatments for knee
osteoarthritis in the community
. Rheumatology (Oxford)43: 381-384.
75.
Kalichman, L.
,
Zhang, Y.Q.
,
Niu, J.B.
,
Goggins, J.
,
Gale, D.
,
Zhu, Y.Y.
et al. (2007a)
The association between patellar alignment on magnetic resonance imaging
and radiographic manifestations of knee osteoarthritis
. Arthritis Res Ther9:
R26
.
76.
Kalichman, L.
,
Zhu, Y.
,
Zhang, Y.
,
Niu, J.
,
Gale, D.
,
Felson, D.T.
et al. (2007b)
The association between patella alignment and knee pain and function: an
MRI study in persons with symptomatic knee osteoarthritis
. Osteoarthritis and Cartilage15: 1235-1240.
77.
Karachalios, T.
,
Zibis, A.
,
Papanagiotou, P.
,
Karantanas, A.H.
,
Malizos, K.N.
,
Roidis, N.
et al. (2004)
MR imaging findings in early osteoarthritis of the knee
. Eur J Radiol50: 225-230.
78.
Kerin, A.
,
Patwari, P.
,
Kuettner, K.
,
Cole, A.
and
Grodzinsky, A.
( 2002)
Molecular basis of osteoarthritis: biomechanical aspects
. Cell Mol Life Sci59: 27-35.
79.
Kirkley, A.
,
Webster-Bogaert, S.
,
Litchfield, R.
,
Amendola, A.
,
MacDonald, S.
,
McCalden, R.
et al. (1999)
The effect of bracing on varus gonarthrosis
. J Bone Joint Surg Am81: 539-548.
80.
Klaue, K.
,
Durnin, C.W.
and
Ganz, R.
( 1991)
The acetabular rim syndrome. A clinical presentation of dysplasia of the
hip
. J Bone Joint Surg Br73: 423-429.
81.
Kurosawa, H.
,
Fukubayashi, T.
and
Nakajima, H.
( 1980)
Load-bearing mode of the knee joint: physical behavior of the knee joint
with or without menisci
. Clin Orthop Relat Res149: 283-290.
82.
Lawrence, R.C.
,
Helmick, C.G.
,
Arnett, F.C.
,
Deyo, R.A.
,
Felson, D.T.
,
Giannini, E.H.
et al. (1998)
Estimates of the prevalence of arthritis and selected musculoskeletal
disorders in the United States
. Arthritis Rheum41: 778-799.
83.
Ledingham, J.
,
Regan, M.
,
Jones, A.
and
Doherty, M.
( 1993)
Radiographic patterns and associations of osteoarthritis of the knee in
patients referred to hospital
. Ann Rheum Dis52: 520-526.
84.
Leunig, M.
,
Werlen, S.
,
Ungersbock, A.
,
Ito, K.
and
Ganz, R.
( 1997)
Evaluation of the acetabular labrum by MR arthrography
. J Bone Joint Surg Br79: 230-234.
Lo, G.H.
,
LaValley, M.
,
McAlindon, T.
and
Felson, D.T.
( 2003)
Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a
meta-analysis
. JAMA290: 3115-3121.
87.
Madsen, O.R.
,
Brot, C.
,
Petersen, M.M.
and
Sorensen, O.H.
( 1997)
Body composition and muscle strength in women scheduled for a knee or hip-
replacement. A comparative study of two groups of osteoarthritic women
. Clin Rheumatol16: 39-44.
88.
Mazieres, B.
,
Scmidely, N.
,
Hauselmann, H.J.
,
Martin-Mola, E.
,
Serni, U.
,
Verbruggen, A.A.
et al. (2005)
Level of acceptability of EULAR recommendations for the management of knee
osteoarthritis by practitioners in differentEuropean countries. Ann Rheum Dis64: 1158-1164.
89.
McAlindon, T.
,
Zhang, Y.
,
Hannan, M.
,
Naimark, A.
,
Weissman, B.
,
Castelli, W.
et al. (1996)
Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis
different
? J Rheumatol23: 332-337.
90.
Messier, S.P.
,
Gutekunst, D.J.
,
Davis, C.
,
DeVita, P.
,
Messier, S.P.
,
Gutekunst, D.J.
et al. (2005)
Weight loss reduces knee-joint loads in overweight and obese older adults
with knee osteoarthritis
. Arthritis Rheumat52: 2026-2032.
91.
Messier, S.P.
,
Loeser, R.F.
,
Miller, G.D.
,
Morgan, T.M.
,
Rejeski, W.J.
,
Sevick, M.A.
et al. (2004)
Exercise and dietary weight loss in overweight and obese older adults with
knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial
. Arthritis Rheum50: 1501-1510.
92.
Mikesky, A.E.
,
Mazzuca, S.A.
,
Brandt, K.D.
,
Perkins, S.M.
,
Damush, T.
and
Lane, K.A.
( 2006)
Effects of strength training on the incidence and progression of knee
osteoarthritis
. Arthritis Rheum55: 690-699.
93.
Misso, M.L.
,
Pitt, V.J.
,
Jones, K.M.
,
Barnes, H.N.
,
Piterman, L.
and
Green, S.E.
( 2008)
Quality and consistency of clinical practice guidelines for diagnosis and
management of osteoarthritis of the hip and knee: a descriptive overview of
published guidelines
. Med J Aust189: 394-399.
94.
Miyazaki, T.
,
Wada, M.
,
Kawahara, H.
,
Sato, M.
,
Baba, H.
and
Shimada, S.
( 2002)
Dynamic load at baseline can predict radiographic disease progression in
medial compartment knee osteoarthritis
. Ann Rheum Dis61: 617-622.
95.
Moseley, J.B.
,
O’Malley, K.
,
Petersen, N.J.
,
Menke, T.J.
,
Brody, B.A.
,
Kuykendall, D.H.
et al. (2002)
A controlled trial of arthroscopic surgery for osteoarthritis of the
knee
. N Eng J Med347: 81-88.
96.
Mundermann, A.
,
Dyrby, C.O.
,
Hurwitz, D.E.
,
Sharma, L.
and
Andriacchi, T.P.
( 2004)
Potential strategies to reduce medial compartment loading in patients with
knee osteoarthritis of varying severity: reduced walking speed
. Arthritis Rheum50: 1172-1178.
97.
Niu, J.
,
Zhang, Y.Q.
,
Nevitt, M.
,
Xu, L.
,
Felson, D.T.
,
Zhu, Y.Y.
et al. (2005)
Patellar malalignment and knee pain among subjects with no radiographic
knee osteoarthritis: The Beijing Osteoarthritis Study
. Arthritis Rheum52:
1191
.
98.
Ogden, C.L.
,
Carroll, M.D.
,
Curtin, L.R.
,
McDowell, M.A.
,
Tabak, C.J.
,
Flegal, K.M.
et al. (2006)
Prevalence of overweight and obesity in the United States, 1999-2004
. JAMA295: 1549-1555.
99.
Ortiz, E.
( 2004)
Market withdrawal of Vioxx: is it time to rethink the use of COX-2
inhibitors
? J Manag Care Pharm10: 551-554.
100.
Ouwens, M.
,
Wollersheim, H.
,
Hermens, R.
,
Hulscher, M.
and
Grol, R.
( 2005)
Integrated care programmes for chronically ill patients: a review of
systematic reviews
. Int J Qual Health Care17: 141-146.
101.
Pencharz, J.N.
,
Grigoriadis, E.
,
Jansz, G.F.
and
Bombardier, C.
( 2002)
A critical appraisal of clinical practice guidelines for the treatment of
lower-limb osteoarthritis
. Arthritis Res4: 36-44.
102.
Poitras, S.
,
Avouac, J.
,
Rossignol, M.
,
Avouac, B.
,
Cedraschi, C.
,
Nordin, M.
et al. (2007)
A critical appraisal of guidelines for the management of knee
osteoarthritis using Appraisal of Guidelines Research and Evaluation
criteria
. Arthritis Res Ther9:
R126
.
103.
Pollo, F.E.
,
Otis, J.C.
,
Backus, S.I.
,
Warren, R.F.
and
Wickiewicz, T.L.
( 2002)
Reduction of medial compartment loads with valgus bracing of the
osteoarthritic knee
. Am J Sports Med30: 414-421.
104.
Rab, G.T.
( 1999)
The geometry of slipped capital femoral epiphysis: implications for
movement, impingement, and corrective osteotomy
. J Pediatr Orthop19: 419-424.
105.
Rao, V.
( 2009) Good or Useless, Medical Scans Cost the Same,
http://www.nytimes.com/2009/03/02/health/02scans.html (accessed July
03, 2009).
106.
Reichenbach, S.
,
Guermazi, A.
,
Niu, J.
,
Neogi, T.
,
Hunter, D.J.
,
Roemer, F.W.
et al. (2008)
Prevalence of bone attrition on knee radiographs and MRI in a
community-based cohort
. Osteoarthritis Cartilage16: 1005-1010.
107.
Roddy, E.
,
Zhang, W.
,
Doherty, M.
,
Arden, N.K.
,
Barlow, J.
,
Birrell, F.
et al. (2005a)
Evidence-based recommendations for the role of exercise in the management
of osteoarthritis of the hip or knee-the MOVE consensus
. Rheumatology (Oxford)44: 67-73.
108.
Roddy, E.
,
Zhang, W.
,
Doherty, M.
,
Roddy, E.
,
Zhang, W.
and
Doherty, M.
( 2005b)
Aerobic walking or strengthening exercise for osteoarthritis of the knee? A
systematic review
. Ann Rheum Dis64: 544-548.
109.
Rosemann, T.
,
Wensing, M.
,
Joest, K.
,
Backenstrass, M.
,
Mahler, C.
and
Szecsenyi, J.
( 2006)
Problems and needs for improving primary care of osteoarthritis patients:
the views of patients, general practitioners and practice nurses
. BMC Musculoskelet Disord7:
48
.
110.
Sarzi-Puttini, P.
,
Cimmino, M.A.
,
Scarpa, R.
,
Caporali, R.
,
Parazzini, F.
,
Zaninelli, A.
et al. (2005)
Do physicians treat symptomatic osteoarthritis patients properly? Results
of the AMICA experience
. Semin Arthritis Rheum35: 38-42.
111.
Schnitzer, T.J.
,
Popovich, J.M.
,
Andersson, G.B.
and
Andriacchi, T.P.
( 1993)
Effect of piroxicam on gait in patients with osteoarthritis of the
knee
. Arthritis Rheum36: 1207-1213.
112.
Seedhom, B.B.
,
Dowson, D.
and
Wright, V.
( 1974)
Proceedings: Functions of the menisci. A preliminary study
. Ann Rheum Dis33:
111
.
113.
Shakoor, N.
and
Moisio, K.
( 2004)
A biomechanical approach to musculoskeletal disease
. Best Pract Res Clin Rheumatol18: 173-186.
114.
Sharma, L.
,
Dunlop, D.D.
,
Cahue, S.
,
Song, J.
and
Hayes, K.W.
( 2003)
Quadriceps strength and osteoarthritis progression in malaligned and lax
knees
. Ann Intern Med138: 613-619.
115.
Sharma, L.
,
Hurwitz, D.E.
,
Thonar, E.J.
,
Sum, J.A.
,
Lenz, M.E.
,
Dunlop, D.D.
et al. (1998)
Knee adduction moment, serum hyaluronan level, and disease severity in
medial tibiofemoral osteoarthritis
. Arthritis Rheum41: 1233-1240.
116.
Sharma, L.
,
Lou, C.
,
Cahue, S.
and
Dunlop, D.D.
( 2000)
The mechanism of the effect of obesity in knee osteoarthritis: the
mediating role of malalignment
. Arthritis Rheum43: 568-575.
117.
Sharma, L.
,
Song, J.
,
Felson, D.T.
,
Cahue, S.
,
Shamiyeh, E.
and
Dunlop, D.D.
( 2001)
The role of knee alignment in disease progression and functional decline in
knee osteoarthritis
. JAMA286: 188-195.
118.
Shelbourne, K.D.
,
Davis, T.J.
and
Klootwyk, T.E.
( 1998)
The relationship between intercondylar notch width of the femur and the
incidence of anterior cruciate ligament tears. A prospective study
. Am J Sports Med26: 402-408.
119.
Slemenda, C.
,
Heilman, D.K.
,
Brandt, K.D.
,
Katz, B.P.
,
Mazzuca, S.A.
,
Braunstein, E.M.
et al. (1998)
Reduced quadriceps strength relative to body weight: a risk factor for knee
osteoarthritis in women
? Arthritis Rheum41: 1951-1959.
120.
Snow, S.W.
,
Keret, D.
,
Scarangella, S.
and
Bowen, J.R.
( 1993)
Anterior impingement of the femoral head: a late phenomenon of
Legg-Calve-Perthes’ disease
. J Pediatr Orthop13: 286-289.
121.
Solomon, L.
( 1976)
Patterns of osteoarthritis of the hip
. J Bone Joint Surg Br58: 176-183.
122.
Tallon, D.
,
Chard, J.
and
Dieppe, P.
( 2000)
Relation between agendas of the research community and the research
consumer
. Lancet355: 2037-2040.
123.
Tanzer, M.
and
Noiseux, N.
( 2004)
Osseous abnormalities and early osteoarthritis: the role of hip
impingement
. Clin Orthop Relat Res429: 170-177.
124.
Teichtahl, A.
,
Wluka, A.
and
Cicuttini, F.M.
( 2003)
Abnormal biomechanics: a precursor or result of knee osteoarthritis
? Br J Sports Med37: 289-290.
125.
Tetsworth, K.
and
Paley, D.
( 1994)
Malalignment and degenerative arthropathy
. Orthop Clin North Am25: 367-377.
126.
Todd, P.A.
and
Clissold, S.P.
( 1990)
Naproxen. A reappraisal of its pharmacology, and therapeutic use in
rheumatic diseases and pain states
. Drugs40: 91-137.
127.
Wolfe, M.M.
,
Lichtenstein, D.R.
and
Singh, G.
( 1999)
Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs
. N Eng J Med340: 1888-1899.
128.
Woolf, S.H.
,
Grol, R.
,
Hutchinson, A.
,
Eccles, M.
and
Grimshaw, J.
( 1999)
Clinical guidelines: potential benefits, limitations, and harms of clinical
guidelines
. BMJ318: 527-530.
129.
Zhang, W.
,
Moskovitz, R.
,
Nuki, G.
,
Abramson, S.
,
Altman, R.
,
Arden, N.
et al. (2008)
OARSI recommendations for the management of hip and knee osteoarthritis,
Part II: OARSI evidence-based, expert consensus guidelines
. Osteoarthritis Cartilage16: 137-162.
130.
Zhang, W.
,
Doherty, M.
,
Arden, N.
,
Bannwarth, B.
,
Bijlsma, J.
,
Gunther, K.P.
et al. (2005)
EULAR evidence based recommendations for the management of hip
osteoarthritis: report of a task force of the EULAR V Standing Committee for
International Clinical Studies Including Therapeutics (ESCISIT)
. Ann Rheum Dis64: 669-681.
