An increasing number of pregnancy complications have been ascribed or at least associated with vitamin D deficiency. Vitamin D has undergone a metamorphosis from nutrient to hormone and more recently has been recognised to have broader biological relevance. This includes potential immunogenic, oncogenic and metabolic actions. This review outlines the roles of vitamin D, the problems in accurate measurement and determining normal ranges and how this is important in an understanding of vitamin D in normal and abnormal pregnancy.
RajakumarK. Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics2003; 112: e132–e135.
2.
LightwoodR. Hypercalcaemia in infants and vitamin D. BMJ1956; 2: 149–149.
3.
FraserDRKodicekE. Unique biosynthesis by kidney of a biologically active vitamin D metabolite. Nature1970; 228: 764–766.
4.
HolickMFSchnoesHKDeLucaHF. Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in the intestine. Biochemistry1971; 10: 2799–2804.
5.
JonesGStrugnellSADeLucaHF. Current understanding of the molecular actions of vitamin D. Physiol Rev1998; 78: 1193–1231.
6.
ProsserDEJonesG. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci2004; 29: 664–673.
7.
HolickM. Vitamin D deficiency. N Engl J Med2007; 357: 266–281.
8.
GarlandCFGarlandFCGorhamED. The role of vitamin D in cancer prevention. Am J Public Health2006; 96: 252–261.
9.
PennaGRoncariAArmuchasteguiS. Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3. Blood2005; 106: 3490–3497.
10.
Nagpal S, Na S and Rathnachalam R 2005 Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26: 662–687.
11.
RosenCJAdamsJSBikleDD. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev2012; 33: 456–492.
12.
LiuPTStengerSLiH. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science2006; 311: 170–173.
13.
MungerKLLevinLIHollisBW. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA2006; 296: 2832–2838.
14.
Nesby-O’DellSScanlonKSCogswellME. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr2002; 76: 187–192.
15.
HeaneyRPDowellMSHaleCA. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr2003; 22: 142–146.
16.
HansenKEJonesANLindstromMJ. Vitamin D insufficiency: disease or no disease?J Bone Miner Res2008; 23: 1052–1060.
17.
BodnarLMCatovJMSimhanHN. Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab2007; 92: 3517–3522.
18.
World Health Organization. Prevention and management of osteoporosis: report of a WHO scientific group, Geneva: World Health Organization, 2003.
19.
SaiAJWaltersRWFangX. Relationship between Vitamin D, parathyroid hormone and bone health. J Clin Endocrinol Metab2011; 96: E436–E446.
20.
KovacsCS. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr2008; 88: 520S–528S.
21.
BouillonRvan BaelenHde MoorP. The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab1977; 45: 225–231.
22.
PoweCESeelyEWRanaS. First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia. Hypertension2010; 56: 758–763.
23.
FarrellCJLMartinSMcWhinneyB. A comparison of automated immunoassays with liquid chromatography–tandem mass spectrometry methods. Clin Chem2012; 58: 531–542.
24.
SattarNWelshPPanarelliM. Increasing requests for vitamin D measurement: costly, confusing, and without credibility. Lancet2012; 379: 95–96.
25.
HollisBWJohnsonDHulseyTC. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res2011; 26: 2341–2357.
26.
SmithHAndersonFRaphaelH. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women: a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology2007; 46: 1852–1857.
27.
SandersKMStuartALWilliamsonEJ. Annual high-dose oral vitamin d and falls and fractures in older women. A randomized controlled trial. JAMA2010; 303: 1815–1822.
