The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Abstract

Background:

The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies in dermatomyositis (DM) is associated with an increased risk of developing rapidly progressive interstitial lung disease (RP-ILD) and a poor prognosis.

Objectives:

We aimed to explore whether tofacitinib could improve the prognosis of Anti-MDA5 antibody positive DM-interstitial lung disease (ILD).

Design:

Systematic review and meta-analysis.

Data Sources and Methods:

Studies were included if they compared mortality rate and infection events in patients with anti-MDA5 antibody positive DM-associated ILD who were treated with or without tofacitinib.

Results:

The systematic review and meta-analysis included a total of 148 patients from four cohort studies. Fifty-eight patients with anti-MDA5 antibody positive DM-ILD who received combined treatment-containing tofacitinib were enrolled in the experimental group. Additionally, 90 DM-ILD patients who did not receive tofacitinib-based therapy were included in the control group. The pooled risk ratio (RR) for all-cause mortality was 0.61 (95% CI, 0.41–0.91, p = 0.02) with I² = 0 indicating no heterogeneity among the included studies. For virus infection risk, the pooled RR was 1.92 (95% CI, 0.90–4.10, p = 0.09), while bacterial and fungal infection-associated RRs were found to be 1.29 (95% CI, 0.65–2.55, p = 0.47) and 1.15 (95% CI, 0.46–2.89, p = 0.77), respectively. There was no statistically significant difference in infection risk between the two groups, and no heterogeneity was observed.

Conclusion:

Our findings suggest that tofacitinib may reduce the risk of all-cause mortality in patients with anti-MDA5 antibody-positive DM-ILD without an increased risk of additional infections.

Trial registration:

PROSPERO: CRD42023445427; https://www.crd.york.ac.uk/prospero/

Plain language summary

Tofacitinib is being utilized in the treatment of a type of dermatomyositis-associated rapidly progressive interstitial lung disease

Why was the study conducted? Currently, despite the utilization of conventional treatments for anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM)-associated interstitial lung disease (ILD), the 6-month mortality rate still remains alarmingly high. Therefore, it is imperative for us to explore novel therapeutic approaches aiming at controlling the rapid progression of this disease.

What did the researchers do? The research team explored mortality rates and infection events in patients with anti-MDA5 antibody-positive DM–ILD who were treated with or without tofacitinib.

What did the researchers find? Our study revealed that tofacitinib resulted in a significant reduction in the risk of all-cause mortality. When considering infection risk, there was no statistically significant difference observed in terms of viral, bacterial, or fungal infections compared with the control group.

What do the findings mean? Our study suggests that tofacitinib demonstrates both efficacy and safety in treating anti-MDA5 positive DM-ILD.

Keywords

anti-melanoma differentiation-associated gene 5 interstitial lung disease tofacitinib dermatomyositis

Introduction

The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies in dermatomyositis (DM) indicates an important subtype of DM,¹ which is prone to rapidly developing progressive interstitial lung disease (RP-ILD).² Despite the application of conventional treatments involving high-dose glucocorticoids (GCs) combined with cyclophosphamide (CYC), or calcineurin inhibitors such as tacrolimus (TAC) and cyclosporine A (CsA), the 6-month mortality rate remains alarmingly high at 50%.³ Therefore, it is imperative for us to explore novel therapeutic approaches aiming at controlling the rapid progression of this disease.

Tofacitinib, a Janus kinase (JAK) inhibitor targeting JAK1 and JAK3, exerts its function by inhibiting the phosphorylation and activation of JAKs. This leads to the prevention of signal transducer and activator of transcription (STAT) phosphorylation and subsequent gene transcription, ultimately resulting in decreased cytokine production and modulation of the immune response.⁴ The effectiveness and safety of tofacitinib have been validated in the treatment of various conditions, including ulcerative colitis (UC),⁵ rheumatoid arthritis (RA),⁶ and psoriatic arthritis.⁷

The pathogenesis of DM is not fully understood, type I IFN signaling plays a crucial role in the development of this disease, which is activated in the muscle and skin of patients with DM.⁸ Inhibiting the JAK-STAT pathway has been found to reduce IFN signaling, supporting the mechanism of action of tofacitinib. Additionally, in vitro research has shown that tofacitinib can inhibit the pro-inflammatory and profibrotic effects by targeting T cells derived from amyopathic dermatomyositis (ADM)-ILD patients.⁹ Clinically, several published studies with small sample sizes have demonstrated the usefulness of tofacitinib in treating anti-MDA5 antibody-positive DM-associated ILD.^10,11

In this systematic review and meta-analysis, we aimed to explore whether tofacitinib could improve the prognosis of anti-MDA5 antibody-positive DM-ILD.

Methods

The search flow diagram, which depicts the systematic review and meta-analysis, is presented in Figure 1. The protocol was conducted in accordance with the PRISMA statement.¹²

Figure 1.

Study selection algorithm.

Search strategy and study selection

The MEDLINE and Embase databases were systematically searched from their inception until July 8, 2023. The search strategy used the term “Dermatomyositis” OR “DM” OR “Idiopathic Inflammatory Myopathy” AND “Tofacitinib” (Supplemental Document 1).

Inclusion criteria

We included studies with patients diagnosed with DM according to the modified Sontheimer’s definition¹³ or Bohan–Peter’s classification criteria¹⁴ or 2017 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria.¹⁵ Additionally, patients had to be anti-MDA5 antibody-positive and had interstitial lesions confirmed by pulmonary computed tomography. The experimental group received treatment with Tofacitinib. Language was not a limiting factor.

Exclusion criteria

Two investigators (Ruyi Zou and Jie Wei) independently reviewed the titles and abstracts of all included studies. Studies were excluded if (1) a full article was unavailable for review, (2) juvenile dermatomyositis, (3) involved animal, or in vitro research, (4) case report or review.

After assessing 13 studies, a total of 9 were excluded: 1 study was excluded due to insufficient survival data, and 8 studies were excluded because they lacked control group. Finally, four eligible studies were included in this study.

Data extraction

Two investigators (Yanhong Wang and Junjie Wang) independently extracted data from each study, including author names, geographical distribution, year of publication, study enrolment period, participant basic characteristics (number, age, sex), infection events, and the number of deaths in both groups. Disagreements between two investigators were settled by arbitration of the principal investigator (Minjie Lin).

Quality assessment

All the included studies are observational researches, and the assessment of bias was conducted using the Newcastle–Ottawa scale.¹⁶ The risk of bias for the included studies was independently assessed by two investigators (Yanhong Wang and Cheng Tang), with any discrepancies resolved through arbitration of the principal investigator (Minjie Lin). A score ⩾ 5 was defined as “low risk of bias,” while studies with scores <5 were regarded as “high risk of bias.”

Outcomes

The primary outcome of this study was to compare risk of all-cause mortality and infection events between anti-MDA5 antibody-positive DM patients with ILD treated with or without tofacitinib. The effect size was estimated as risk ratio (RR) with 95% confident interval (CI).

Statistics

We extracted the survival rate and number of infection events in two groups from eligible studies, and pooled the data using a random-effect model.

The statistical heterogeneity of effect size across the included studies was assessed using both the Cochrane Q test and I² statistic. p-Value of <0.1 on the Q test was considered statistically significant. Heterogeneity levels were categorized as acceptable (0%–50%) or high (51%–100%).¹⁷ Funnel plot, Egger’s test, and Begg’s test were utilized to evaluate publication bias. All statistical analyses were conducted using RevMan5.4 and Stata 11 SE.

Results

Out of the 444 articles or abstracts initially identified in our search, 431 were excluded after a thorough review of their titles and abstracts. Subsequently, we conducted a full-text review of 13 articles and ultimately included four in our final meta-analysis (Figure 1).^3,18–20

Characteristics of the included studies

The included studies consisted solely of cohort studies. A total of 58 patients with anti-MDA5 antibody-positive dermatomyositis-associated interstitial lung disease (DM-ILD) who received combined treatment containing tofacitinib were enrolled in the meta-analysis. Additionally, 90 DM-ILD patients who did not receive tofacitinib-based therapy were included in the control group. All studies were evaluated using the Newcastle–Ottawa scale, and a score of 8 was achieved (Table 1), indicating that the included studies are of high quality.

Table 1.

Summary of included studies.

Studies	Geographical distribution	Public Time	Study enrolment Period	Conventional therapy combined Tofacitinib					Conventional therapy					Newcastle-Ottawa scale
Studies	Geographical distribution	Public Time	Study enrolment Period	Sample size	Sex (M)	Age	Conventional therapy	Dead during follow-up period	Sample size	Sex (M)	Age	Conventional therapy	Dead during follow-up period	Newcastle-Ottawa scale
Chen et al.	China	2019	2014–2018	18	7	47.6 ± 13.8	Glucocorticoid, Cyclosporine, Mycophenolate mofetil	0	32	7	52.5 ± 10.6	Glucocorticoid, Cyclosporine, Mycophenolate mofetil, Cyclophosphamide, Azathioprine	7	8
Fan et al.	China	2022	2017–2020	26	11	55.42 ± 2.20	Glucocorticoid	12	35	13	55.94 ± 1.72	Glucocorticoid, Tacrolimus	23	8
Kurasawa et al.	Japan	2014	NA	5	2	60(51–70)	Glucocorticoid, Cyclosporine, Cyclophosphamide	2	6	4	63(60–72)	Glucocorticoid, Cyclosporine, Cyclophosphamide	6	8
Shirai et al.	Japan	2023	2014–2021	8	3	50.4 ± 17.8	Glucocorticoid, Cyclosporine, Tacrolimus	2	17	3	51.8 ± 9.1	Glucocorticoid, Cyclosporine, Tacrolimus	8	8

Efficacy and infection events of tofacitinib

The pooled RR for all-cause mortality was 0.61 (95% CI, 0.41–0.91, p = 0.02), with an I² value of 0. In tofacitinib group, 16 out of 57 patients died during follow-up period, resulting in a mortality rate of 28.07%, while in the control group, there were 44 deaths out of 90 patients, resulting in a mortality rate of 48.89% (Figure 2). The pooled RR for virus infection risk was 1.92 (95% CI, 0.90–4.10, p = 0.09; Figure 3), and bacterial infection-associated RR was 1.29 (95% CI, 0.65–2.55, p = 0.47; Figure 4), and for fungal infection, the associated RR was calculated as1.15 (95% CI, 0.46–2.89, p = 0.77; Figure 5). In the tofacitinib group, 10/57(17.54%) patients suffered from virus infection, 6/31 (19.35%) suffered from bacterial infection, and 7/31 (22.58%) suffered from fungal infection when the control group were 7/41 (17.07%), 5/41 (12.20%), and 8/41 (19.51%) respectively, with no heterogeneity found (I² = 0; Figure 3 –5). Only two studies were included in Figures 3 –5, because the other studies did not contain the needed information about infection.

Figure 2.

Forest plot for pooled risk ratio for all-cause mortality.

Figure 3.

Forest plot for pooled risk ratio for virus infection risk.

Figure 4.

Forest plot for pooled risk ratio for bacterial infection risk.

Figure 5.

Forest plot for pooled risk ratio for fungal infection risk.

Evaluation of publication bias

The funnel plot appeared to indicate potential publication bias across the four studies using RevMan 5.4 (Supplemental Figure 1). However, after reanalysis with Egger’s and Begg’s methods using Stata 11 SE (Supplemental Figures 2 and 3, Supplement Table 2), there was no statistical significance. Therefore, we concluded that studies included in the analysis did not have publication bias.

Discussion

This systematic review and meta-analysis included 148 patients from 4 studies (58 anti-MDA5 antibody positive DM- ILD treated with tofacitinib and 90 patients without tofacitinib). The findings suggest that tofacitinib may reduce the risk of all-cause mortality. Regarding infection risk, there was no statistical significance in the occurrence of viral, bacterial, or fungal infections between the two groups.

Patients with anti-MDA5 antibody-positive DM are prone to developing ILD, particularly RP-ILD.²¹ Although the specific pathogenic mechanisms of anti-MDA5 antibody-positive DM-ILD are unknown, potential environmental triggers, especially viral infections and genetic susceptibility have been indicated to play a role in this disease.²² MDA5 protein is encoded by the interferon-induced helicase C domain 1 (IFIH1) gene. It functions as a sensor for detecting the presence of viruses and gets activated by viral RNA. Its activation is necessary for viral immunity but can also lead to interferon-driven auto-inflammatory diseases.²² Certain human leukocyte antigen (HLA) regions, such as HLA-DRB1*0101, *0405, *1201, *0901, *0401, and *1202 have been found to be associated with susceptibility to anti-MDA5 antibody positive DM.^23–25 During this process, several components of the type I IFN signaling pathways play crucial roles including IFN-induced protein with tetratricopeptide repeats 2(IFIT2), IFN-induced protein with tetratricopeptide repeats 3(IFIT3), myxovirus resistance 1 (MX1), interferon regulatory factor 7 (IRF7), C-C motif ligand 2 (CCL2), and clusterin (GLU).²⁶

Due to the high mortality rate of anti-MDA5 antibody-positive DM, especially combined with ILD, there is an urgent need for novel therapies. Currently, pirfenidone, plasma exchange, rituximab, intravenous immunoglobulin, and tofacitinib are being applied (1). Tofacitinib, a JAK inhibitor widely used in rheumatoid arthritis (RA), has shown efficacy as a monotherapy in reducing signs and symptoms of RA and improving physical function.²⁷ Up to 8.5 years’ follow-up results have demonstrated a low incidence of adverse events including opportunistic infections, tuberculosis, tumors, cardiovascular events, and gastrointestinal perforation.²⁸ Additionally, a survey conducted in the United States using email questionnaires found that 56.4% of patients were more inclined to choose oral medication such as tofacitinib over biologics that required injection.²⁹ Based on its efficacy, safety, and convenience, tofacitinib has been applied in the treatment of anti-MDA5 antibody-positive DM. Chen et al.’s³ study demonstrates that compared to a historical control group (25 out of 32, 78%), a combination regimen with tofacitinib can improve the survival rate of anti-MDA5 antibody-positive DM-ILD within 6 months after ILD onset (18 out of 18, 100%). In a prospective open-label pilot study on refractory DM, patients treated with tofacitinib showed an improvement in median total improvement score (TIS) with five out of ten patients (50%) experiencing moderate improvement and the other half experiencing minimal improvement on TIS. Additionally, the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) significantly decreased from 28 ± 15.4 to 9.5 ± 8.5 (p = 0.0005).³⁰ In newly onset adults with anti-MDA5 antibody-positive DM, tofacitinib also demonstrated efficacy. According to Wang et al.s’¹⁰ study, responses were observed in 10 patients (71.4%) after 6 months of treatment with GCs combined with tofacitinib, with two patients achieving major improvement, seven achieving moderate improvement, and one achieving minimal improvement. Furthermore, studies about anti-MDA5 antibody-positive DM suggested that the rate of adverse events of tofacitinib was very low.^3,18 Tofacitinib has two dosages, an 11 mg once-daily extended-release formulation and a 5 mg twice-daily immediate-release formulation. In our four included studies, three studies used the 5 mg immediate-release formulation, while one study did not describe the drug dosage and formulation. Observations by Wang et al.³¹ suggest that the extended-release tofacitinib formulations have therapeutic efficacy in controlling disease activity of refractory Behçet’s disease. Considering the convenience of the extended-release formulation, we plan to use it in the future in our center for anti-MDA5 antibody-positive DM-ILD.

Advantages and limitations

To the best of our knowledge, this is the first systematic review and meta-analysis that focuses on the efficacy and safety of tofacitinib in anti-MDA5 positive DM-ILD. Furthermore, all results demonstrate homogeneity, which enhances the robustness of our conclusions. However, our study has several limitations. Notably, the number of patients included in our study is small. Second, all four studies included are cohort studies and prospective randomized controlled trials are needed. Additionally, there were variations in the severity of anti-MDA5 antibody-positive DM-ILD among patients, and severe cases were more likely to receive tofacitinib, potentially leading to confounding and selection bias. Finally, all four studies involved patients from Japan and China, and different human races may exhibit distinct clinical characteristics and responses to tofacitinib.

Conclusion

Our findings suggest that tofacitinib could decrease the risk of all-cause mortality in patients with anti-MDA5 antibody-positive DM-ILD without increasing infection risk. We look forward to more randomized controlled trials being carried out in the future to validate this conclusion.

Supplemental Material

sj-docx-1-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-docx-1-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Supplemental Material

sj-docx-2-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-docx-2-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Supplemental Material

sj-docx-3-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-docx-3-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Supplemental Material

sj-png-4-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-png-4-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Supplemental Material

sj-png-5-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-png-5-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Supplemental Material

sj-png-6-tar-10.1177_17534666241294000 – Supplemental material for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis

Supplemental material, sj-png-6-tar-10.1177_17534666241294000 for The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis by Yanhong Wang, Ruyi Zou, Jie Wei, Cheng Tang, Junjie Wang and Minjie Lin in Therapeutic Advances in Respiratory Disease

Footnotes

Appendix

Acknowledgements

We would like to express our gratitude to Chuanjun Xu for his contribution in refining the article.

Declaration

ORCID iD

Minjie Lin

Supplemental material

Supplemental material for this article is available online.

References

McPherson

Economidou

Liampas

, et al. Management of MDA-5 antibody positive clinically amyopathic dermatomyositis associated interstitial lung disease: a systematic review. Semin Arthritis Rheu 2022; 53: 151959.

Chen

Cao

Plana

, et al. Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthrit Care Res 2013; 65(8): 1316–1324.

Chen

Wang

. Tofacitinib in amyopathic dermatomyositis-associated interstitial lung disease. New Engl J Med 2019; 381(3): 291–293.

Jiang

Ghoreschi

Deflorian

, et al. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J Med Chem 2008; 200851(24): 8012–8018.

Lopez-Sanroman

Esplugues

Domenech

. Pharmacology and safety of tofacitinib in ulcerative colitis. Gastroent Hepat-Barc 2021; 44(1): 39–48.

Dhillon

. Tofacitinib: a review in rheumatoid arthritis. Drugs 2017; 77(18): 1987–2001.

Mease

Hall

FitzGerald

, et al. Tofacitinib or Adalimumab versus Placebo for Psoriatic Arthritis. New Engl J Med 2017; 377(16): 1537–1550.

Greenberg

. Sustained autoimmune mechanisms in dermatomyositis. J Pathol 2014; 233(3): 215–226.

Wang

Zhao

Chen

, et al. CD4+CXCR4+ T cells as a novel prognostic biomarker in patients with idiopathic inflammatory myopathy-associated interstitial lung disease. Rheumatology 2019; 58(3): 511–521.

10.

Wang

Luo

, et al. Tofacitinib for new-onset adult patients with anti-melanoma differentiation-associated 5 gene antibody positive dermatomyositis. Clin Rheumatol 2023; 42(7): 1847–1853.

11.

Ida

Furuta

Takayama

, et al. Efficacy and safety of dose escalation of tofacitinib in refractory anti-MDA5 antibody-positive dermatomyositis. RMD Open 2023; 9: e002795.

12.

Page

McKenzie

Bossuyt

, et al. Updating guidance for reporting systematic reviews: development of the PRISMA 2020 statement. J Clin Epidemiol 2021; 134: 103–112.

13.

Sontheimer

. Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sine myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? J Am Acad Dermatol 2002; 46(4): 626–636.

14.

Bohan

Peter

. Polymyositis and dermatomyositis (first of two parts). New Engl J Med 1975; 292(7): 344–347.

15.

Lundberg

Tjarnlund

Bottai

, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis 2017; 76(12): 1955–1964.

16.

Stang

. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25(9): 603–605.

17.

Higgins

Thompson

Deeks

, et al. Measuring inconsistency in meta-analyses. BMJ Brit Med J 2003; 327(7414): 557–560.

18.

Fan

Lyu

Liu

, et al. A retrospective analysis of outcome in melanoma differentiation-associated gene 5-related interstitial lung disease treated with tofacitinib or tacrolimus. J Rheumatol 2022; 49(12): 1356–1364.

19.

Shirai

Machiyama

Sato

, et al. Intensive induction therapy combining tofacitinib, rituximab and plasma exchange in severe anti-melanoma differentiation-associatedprotein-5 antibody-positive dermatomyositis. Clin Exp Rheumatol 2023; 41(2): 291–300.

20.

Kurasawa

Arai

Namiki

, et al. Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis. Rheumatology 2018; 57(12): 2114–2119.

21.

Liu

Cheng

, et al. Roles of biomarkers in anti-MDA5-positive dermatomyositis, associated interstitial lung disease, and rapidly progressive interstitial lung disease. J Clin Lab Anal 2022; 36(11): e24726.

22.

Dias

Sampaio

Rehwinkel

. A balancing act: MDA5 in antiviral immunity and autoinflammation. Trends Microbiol 2019; 27(1): 75–85.

23.

Gono

Kawaguchi

Kuwana

, et al. Brief report: Association of HLA-DRB1*0101/*0405 with susceptibility to anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis in the Japanese population. Arthritis Rheum 2012; 64(11): 3736–3740.

24.

Lin

Zhang

Peng

, et al. Genetic association of HLA-DRB1 multiple polymorphisms with dermatomyositis in Chinese population. HLA 2017; 90(6): 354–359.

25.

Chen

Wang

Kuwana

, et al. HLA-DRB1 alleles as genetic risk factors for the development of anti-MDA5 antibodies in patients with dermatomyositis. J Rheumatol 2017; 44(9): 1389–1393.

26.

Gono

Okazaki

Kuwana

. Antiviral proinflammatory phenotype of monocytes in anti-MDA5 antibody-associated interstitial lung disease. Rheumatology 2022; 61(2): 806–814.

27.

Fleischmann

Kremer

Cush

, et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. New Engl J Med 2012; 367(6): 495–507.

28.

Cohen

Tanaka

Mariette

, et al. Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials. Ann Rheum Dis 2017; 76(7): 1253–12662.

29.

Louder

Singh

Saverno

, et al. Patient preferences regarding rheumatoid arthritis therapies: a conjoint analysis. Am Health Drug Benef 2016; 9(2): 84–93.

30.

Paik

Casciola-Rosen

Shin

, et al. Study of tofacitinib in refractory dermatomyositis: an open-label pilot study of ten patients. Arthritis Rheumatol 2021; 73(5): 858–865.

31.

Chrong-Reen Wang

Tak-Wah Wong

, et al. Extended-release tofacitinib for refractory Behçet disease. Medicine 2022; 101(15): e29189.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.02 MB

0.01 MB

0.03 MB

0.00 MB

0.01 MB