Malignant bone tumours of the hands are uncommon. Although almost all lesions that occur in other parts of the skeleton can also affect the hands, their frequency, distribution and clinical characteristics differ. This review focusses on the histology of these tumours and gives an overview of the main differential diagnoses. Close correlation to radiologic and clinical features usually leads to the correct diagnosis.
Abe K., Kumagai K., Hayashi T. et al. High-grade surface osteosarcoma of the hand. Skeletal Radiol. 2007, 36: 869-73.
2.
Abramovici L., Steiner GCBizarre parosteal osteochondromatous proliferation (Nora’s lesion): a retrospective study of 12 cases, 2 arising in long bones. Hum Pathol. 2002, 33: 1205-10.
3.
Baraga JJ, Amrami KK, Swee RG, Wold L., Unni KKRadiographic features of Ewing’s sarcoma of the bones of the hands and feet. Skeletal Radiol. 2001, 30: 121-6.
4.
Baranowski D., Edel G., Klein W., Blasius S.Fallbericht Angiosarkom der Hand - Falldarstellung. Handchir Mikrochir Plast Chir. 1997, 29: 147-52.
5.
Bauer TW, Dorfman HD, Latham Jr JTPeriosteal chondroma. A clinicopathologic study of 23 cases. Am J Surg Pathol.1982, 6: 631-7.
Bernstein M., Kovar H., Paulussen M. et al. Ewing’s sarcoma family of tumors: current management. Oncologist. 2006, 11: 503-19.
8.
Bertoni F., Bacchini P., Hogendoorn PCW.Chondrosarcoma. In: Fletcher CDM , Unni KK, Mertens F (Eds.) WHO: pathology and genetics of tumours of the soft tissue and bone. Lyon, France, IARCPress, 2002: 247-51.
9.
Bertoni F., Biscaglia R., Bacchini P.Giant cell reparative granuloma of the phalanx of the hand with aggressive radiographic features. Skeletal Radiol. 1998 , 27: 584-7.
10.
Bielack SS, Kempf-Bielack B., Delling G. et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol. 2002, 20: 776-90.
11.
Bovée JV, van der Heul RO, Taminiau AH, Hogendoorn PCChondrosarcoma of the phalanx: a locally aggressive lesion with minimal metastatic potential: a report of 35 cases and a review of the literature . Cancer. 1999, 86: 1724-32.
12.
Bovée JV, van Roggen JF, Cleton-Jansen AM, Taminiau AH, van der Woude HJ, Hogendoorn PCMalignant progression in multiple enchondromatosis (Ollier’s disease): an autopsy-based molecular genetic study. Hum Pathol . 2000, 31: 1299-303.
13.
Brien EW, Mirra JM, Kerr R.Benign and malignant cartilage tumors of bone and joint: their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology. I. The intramedullary cartilage tumors. Skeletal Radiol. 1997, 26: 325-53.
14.
Choi JH, Gu MJ, Kim MJ, Choi WH, Shin DS, Cho KHFibrosarcoma in bizarre parosteal osteochondromatous proliferation . Skeletal Radiol. 2001, 30: 44-7.
Cotterill SJ, Ahrens S., Paulussen M. et al. Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol. 2000, 18: 3108-14.
17.
Daecke W., Ahrens S., Juergens H. et al. Ewing’s sarcoma and primitive neuroectodermal tumor of hand and forearm. Experience of the Cooperative Ewing’s Sarcoma Study Group . J Cancer Res Clin Oncol.2005a, 131: 219-25.
18.
Daecke W., Bielack S., Martini AK et al. Osteosarcoma of the hand and forearm: experience of the Cooperative Osteosarcoma Study Group. Ann Surg Oncol. 2005b, 12: 322-31.
19.
de Silva MV, Reid R.Myositis ossificans and fibroosseous pseudotumor of digits: a clinicopathological review of 64 cases with emphasis on diagnostic pitfalls. Int J Surg Pathol. 2003, 11: 187-95.
20.
Debruyne PR, Dumez H., Demey W., Gillis L., Sciot R., Schoffski P.Recurrent low- to intermediate-grade chondrosarcoma of the thumb with lung metastases: an objective response to trofosfamide. Onkologie . 2007, 30: 201-4.
21.
Doganavsargil B., Argin M., Sezak M. et al. Dedifferentiated chondrosarcoma of the thumb: a case report. Arch Orthop Trauma Surg.2009, 129: 161-6.
22.
Durbin M., Randall RL, James M., Sudilovsky D., Zoger S.Ewing’s sarcoma masquerading as osteomyelitis. Clin Orthop. 1998: 176-85.
23.
Engels C., Werner M., Delling G.[Clear-cell chondrosarcoma]. Pathologe. 2000 , 21: 449-55.
24.
Evans HL, Ayala AG, Romsdahl MMPrognostic factors in chondrosarcoma of bone. Cancer . 1977, 40: 818-31.
25.
Flint JH, McKay PLBizarre parosteal osteochondromatous proliferation and periosteal chondroma: a comparative report and review of the literature. J Hand Surg Am. 2007, 32: 893-8.
26.
Fowble VA, Pae R., Vitale A., Bryk E., Vigorita VJCase reports: osteosarcoma of the hand: one case and a literature review. Clin Orthop Relat Res. 2005, 440: 255-61.
27.
Frassica FJ, Amadio PC, Wold LE, Dobyns JH, Linscheid RLPrimary malignant bone tumors of the hand. J Hand Surg Am . 1989, 14: 1022-8.
28.
Greenspan A., Jundt G., Remagen W.Round cell lesions. Differential diagnosis in orthopaedic oncology , 2nd Edn. Philadelphia, USA , Lippincott Williams & Wilkins, 2007: 314-62.
29.
Gruber G., Giessauf C., Leithner A. et al. Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature. Can J Surg. 2008, 51: 486-9.
30.
Honda H., McDonald JRCurrent recommendations in the management of osteomyelitis of the hand and wrist. J Hand Surg Am.2009.
31.
Jambhekar NA, Bagwan IN, Ghule P. et al. Comparative analysis of routine histology, immunohistochemistry, reverse transcriptase polymerase chain reaction, and fluorescence in situ hybridization in diagnosis of Ewing family of tumors. Arch Pathol Lab Med. 2006, 130: 1813-18.
32.
Jambhekar NA, Desai SS, Puri A., Agarwal M.Florid reactive periostitis of the hands. Skeletal Radiol . 2004, 33: 663-5.
33.
Jerome TJ, Varghese M., Sankaran B.Ewing’s sarcoma of the distal phalanx of the little finger. J Hand Surg Eur. 2008, 33: 81-2. Jones KB, Buckwalter JA, McCarthy EFParosteal osteosarcoma of the thumb metacarpal: a case report. Iowa Orthop J. 2006, 26: 134-7.
34.
Jundt G., Moll C., Nidecker A., Schilt R., Remagen W.Primary leiomyosarcoma of bone. Report of eight cases. Hum Pathol. 1994, 25: 1205-12.
35.
Khedhaier A., Maalla R., Ennouri K., Regaya N.Soft tissues chondromas of the hand: a report of five cases. Acta Orthop Belg. 2007, 73: 458-61.
36.
MacDonald DF, Binhammer PA, Rubenstein JD, Fornasier VLGiant cell reparative granuloma of the hand: case report and review of giant cell lesions of hands and feet. Can J Surg. 2003, 46: 471-3.
37.
Mathov SH, Bougie JD, Awad S.Osteosarcoma of the hand: a rare case for radiographic appearance, location, and age. J Manipulative Physiol Ther. 2008 , 31: 164-7.
38.
Meier VS, Kühne T., Jundt G., Gudat F.Molecular diagnosis of Ewing tumors: improved detection of EWS-FLI-1 and EWS-ERG chimeric transcripts and rapid determination of exon combinations . Diagn Mol Pathol. 1998, 7: 29-35.
39.
Mertens F., Unni KKEnchondromatosis: Ollier disease and Maffucci syndrome. In: Fletcher CDM, Unni KK, Mertens F (Eds.) WHO: pathology and genetics of tumours of the soft tissue and bone. Lyon, France, IARC Press, 2002: 356-7.
40.
Mirra JM, Gold R., Downs J., Eckardt JJA new histologic approach to the differentiation of enchondroma and chondrosarcoma of the bones. A clinicopathologic analysis of 51 cases. Clin Orthop. 1985, 201: 214-37.
41.
Muir TM, Lehman TP, Meyer WHPeriosteal osteosarcoma in the hand of a pediatric patient: a case report . J Hand Surg Am. 2008, 33: 266-8.
42.
Nilsson M., Domanski HA, Mertens F., Mandahl N.Molecular cytogenetic characterization of recurrent translocation breakpoints in bizarre parosteal osteochondromatous proliferation (Nora’s lesion) . Hum Pathol. 2004, 35: 1063-9.
43.
Nora FE, Dahlin DC, Beabout JWBizarre parosteal osteochondromatous proliferation of the hands and feet. Am J Surg Pathol. 1983, 7: 245-50.
44.
Okada K., Wold LE, Beabout JW, Shives TCOsteosarcoma of the hand. A clinicopathologic study of 12 cases. Cancer. 1993, 72: 719-25.
45.
Ostrowski ML, Spjut HJLesions of the bones of the hands and feet. Am J Surg Pathol . 1997, 21: 676-90.
46.
Pannier S., Legeai-Mallet L.Hereditary multiple exostoses and enchondromatosis. Best Pract Res Clin Rheumatol. 2008, 22: 45-54.
47.
Patil S., de Silva MV, Crossan J., Reid R.Chondrosarcoma of small bones of the hand. J Hand Surg Br . 2003, 28: 602-8.
48.
Paulussen M., Ahrens S., Dunst J. et al. Localized Ewing tumor of bone: final results of the cooperative Ewing’s Sarcoma Study CESS 86. J Clin Oncol. 2001, 19: 1818-29.
49.
Peydro-Olaya A., Llombart-Bosch A., Carda-Batalla C., Lopez-Guerrero JAElectron microscopy and other ancillary techniques in the diagnosis of small round cell tumors. Semin Diagn Pathol. 2003 , 20: 25-45.
50.
Raymond AK, Ayala AG, Knuutila S.Conventional osteosarcoma. In: Fletcher CDM, UnniI KK, Mertens F (Eds.) WHO: pathology and genetics of tumours of the soft tissue and bone. Lyon, IARCPress, 2002: 264-72.
51.
Reilly KE, Linz JC, Stern PJ, Giza E., Wyrick JDOsteomyelitis of the tubular bones of the hand. J Hand Surg Am. 1997, 22: 644-9.
52.
Revell MP, Mulligan PJ, Grimer RJParosteal osteosarcoma of the ring finger metacarpal in a semi-professional pianist. J Hand Surg Br. 2000, 25: 314-16.
53.
Sanerkin NGThe diagnosis and grading of chondrosarcoma of bone. A combined cytologic and histologic approach. Cancer. 1980, 45: 582-94.
54.
Shimpuku E., Lee YH, Oka Y.Periosteal chondroma of the proximal phalanx of the thumb. Scand J Plast Reconstr Surg Hand Surg. 2002, 36: 125-7.
55.
Spjut HJ, Dorfman HDFlorid reactive periostitis of the tubular bones of the hands and feet. A benign lesion which may simulate osteosarcoma. Am J Surg Pathol.1981, 5: 423-33.
56.
Tos P., Artiaco S., Linari A., Battiston B.Chondrosarcoma in the distal phalanx of index finger: clinical report and literature review. Chir Main. 2009, 28: 265-9.
57.
Unni KK, Inwards CY, Bridge JA, Kindblom L., Wold L.Conditions that simulate primary neoplasm of bone. In: Silverberg SG, Sobin LH (Eds.) AFIP atlas of tumor pathology, tumors of the bones and joints, fourth series, fascicle 2. Washington DC, ARP Press , 2005.
58.
Ushigome S., Machinami R., Sorensen PHEwing Sarcoma/ Primitive Neuroectodermal Tumour (PNET). In: Fletcher CDM, Unni KK, Mertens F (Eds.) WHO: pathology and genetics of tumours of the soft tissue and bone. Lyon, IARCPress, 2002 : 298-300.
59.
Welkerling H., Kratz S., Ewerbeck V., Delling G.A reproducible and simple grading system for classical chondrosarcomas. Analysis of 35 chondrosarcomas and 16 enchondromas with emphasis on recurrence rate and radiological and clinical data. Virchows Arch. 2003, 443: 725-33.
60.
Woertler K., Blasius S., Brinkschmidt C., Hillmann A., Link TM, Heindel W.Periosteal chondroma: MR characteristics. J Comput Assist Tomogr. 2001, 25: 425-30.
61.
Yamaguchi T., Dorfman HDGiant cell reparative granuloma: a comparative clinicopathologic study of lesions in gnathic and extragnathic sites. Int J Surg Pathol . 2001, 9: 189-200.
62.
Yamaguchi T., Tamai K., Saotome K., Hoshino T., Masawa N.Ewing’s sarcoma of the thumb. Skeletal Radiol . 1997, 26: 725-8.
63.
Yuen M., Friedman L., Orr W., Cockshott WPProliferative periosteal processes of phalanges: a unitary hypothesis . Skeletal Radiol. 1992, 21: 301-3.