This case report describes the precipitation of serotonin syndrome in a patient taking a selective serotonin reuptake inhibitor, by infusion of methylene blue dye during a parathyroidectomy procedure. Methylene blue acts as a monamine oxidase inhibitor, thus increasing levels of serotonin in the brain. The authors describe the diagnosis and management of serotonin syndrome and suggest that more caution be exercised in the use of methylene blue.
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Food and Drug Administration Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications. http://www.fda.gov/Drugs/DrugSafety/ucm263190.htm Accessed 09/12/2011.
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