A 34-year-old man took a mixed overdose of multiple lipid-soluble drugs. He did not respond to maximal medical therapy but improved after the introduction of Intralipid. The possible mechanisms of action and potential adverse consequences of using Intralipid in this context are reviewed.
CaveGHarrop-GriffithsWHarveyM. Management of severe local anaesthetic toxicity.Association of Anaesthetics of Great Britain and Ireland. 2010.
5.
Turner-LawrenceDKernsW. Intravenous fat emulsion: A potential novel antidote. J Medical Toxicol2008;4.
6.
BrullSJ. Lipid emulsion for the treatment of local anaesthetic toxicity: Patient safety implicationsAnesthesia Anal2008;106: 1337.
7.
SchoffskiPFreundMWunderR. Safety and toxicity of Amphotericin B in glucose 5% or Intralipid 20% in neutropenic patients with pneumonia or fever of unknown origin: randomised study. Br Med J1998;317: 379.