We describe the case of a young male, found collapsed following poisoning with an unknown substance. He had a Glasgow Coma Score (GCS) of three with a profound metabolic acidosis, despite poisoning with a substance which was strongly basic. He was treated with haemodiafiltration to correct the biochemical derangements. The poison was found to be cyanide, so the patient was also given sodium thiosulphate as an antidote. We review the pathophysiology of cyanide toxicity, the antidotes available and discuss the role of haemodiafiltration in poisoning where the ingested substance is unknown.
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